antimicrobial action

Microparticles based on natural Transcarpathian clinoptilolite (CL), its H- and Na-forms are synthesized by physicochemical modifications, in particular, heat treatment and doping with metal activators (Ag and Cu). Doping of CL samples with metal ions was carried out in two different ways: the first was to use the solid-phase extraction method under dynamic conditions followed by mechanochemical treatment, and the second was to mechanochemically treat the CL samples with Ag and Cu compounds.

The paper presents the results of research on the development of a potential drug that consists of S-ethyl ester of 4-acetylaminobenzene sulfonic acid and excipients in the powder dosage form for topical use. The powder composition was substantiated on the basis of microbiological studies of the introduced compound and the dosage form based on it. The rational content of the compound as a biologically active substance in the powder was established. The optimal composition of excipients was selected.