тіосульфонати

Obtaining and Determining Antiviral and Antibacterial Activity of S-Esters of 4-R-Aminobenzenethiosulfonic Acid

A number of S-esters of 4-R-aminobenzene¬thiosulfonic acids were synthesized via alkylation of the sodium salt of 4-acetylaminobenzenethiosulfonic acid with various alkylating agents and acylation of the corresponding esters of 4-aminobenzenethiosulfonic acid with metha-cryloyl chloride. For obtaining S-methyl 4-(acetyla-mino)benzenesulfonothioate, it was developed a synthetic technique corresponding to the basic principles of "green chemistry". The degree of compound cytotox-icity was measured by determining A-549 cell growth using colorimetric method.

Synthesis and properties of 4,6-dimethylpyrimidine-2-yl esters of aromatic thiosulfoacids.

Methods for the synthesis of thiosulfoesters with a pyrimidine moiety were investigated by the interaction of sulfinic acids with 4,6-dimethylpyrimidine-2-yl sulfenamide. The interaction of 4,6-dimethylpyrimidin-2-yl esters of aromatic thiosulfoacids with amines (benzylamine, morpholine, ammonia) was investigated.

SYNTHESIS AND PROPERTIES OF 4-AMINO-2-METHYL-PYRIMIDINE-5-IL-METHYL ESTERS OF AROMATIC THIOSULFOACIDS

Derivatives of pyrimidine are the object of interest to researchers working in the field of medical chemistry. However, despite the rich history of searching for potential biologically active agents among substances containing this heterocyclic fragment, their potential is still unused. There are vitamins, vasodilators, antidiabetic, antibacterial, antimalarial substances among the derivatives of pyrimidine. A special group among the biologically active compounds is sulfurcontaining derivatives of pyrimidine (sulfides, salts of sulfonic acids, sulfonamides, sulfenamides, disulfides).

SYNTHESIS OF TIOSOLFOESTERS WITH S-TRIAZINE FRAGMENT

Cyanuric chloride is a valuable starting agent for the direct obtaining of highly structured molecules. The substitution of chlorine atoms in the molecule of cyanuric chloride by various pharmacophores’ fragments provides the obtaining a number of 1,3,5-triazine derivatives, among which the promising biologically active substances showing antimicrobial, anticancer, antimalarial and antiviral activity were detected.