3-(4-Acetylphenyl)-(2-methyl)-2-chloro(bromo, thiocyanato)propanamides have been obtained via copper catalytic anionarylation of acrylic and methacrylic acids amides by 4-acetylphenyldiazonium salts. 5-(4-Acetylphenyl)substituted 2-aminothiazol-4(5H)-ones were synthesized by cyclisation of thiocyanatoamides. All synthesized compounds were tested for their antibacterial and antomycotic activity.
[1] O'Neil M. (Ed.): The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 15th edn. Merck and Co. Inc., Cambridge 2013.
[2] Cripps R.: Biochem J., 1975, 152, 233. https://doi.org/10.1042/bj1520233
[3] Salas P., Soto A., Carretero A. et al.: Molecules, 2010, 15, 8813. https://doi.org/10.3390/molecules15128813
[4] Pharmaceutical Manufacturing Encyclopedia. William Andrew Publishing, Norwich, NY 2007.
[5] Shen Y., Li B., Xu H. et al.: Pharmazie, 2013, 68, 307.
[6] Wang Z., Li X., Xu W. et al.: Med. Chem. Commun., 2015, 6, 2146. https://doi.org/10.1039/C5MD00357A
[7] Baranovskii V., Simchak R., Grishchuk B.: Russ. J. Gen. Chem., 2009, 79, 269. https://doi.org/10.1134/S1070363209020170
[8] Baranovskii V., Yatsyuk V., Grishchuk B.: Russ. J. Gen. Chem., 2014, 84, 1505. https://doi.org/10.1134/S1070363214080106
[9] Grishchuk B., Baranovskii V., Klymnyuk S. et al.: Pharm. Chem. J., 2011, 45, 532. https://doi.org/10.1007/s11094-011-0673-0
[10] Grishchuk B., Simchak R., Baranovskii V. et al.: Pharm. Chem. J., 2013, 47, 307. https://doi.org/10.1007/s11094-013-0949-7
[11] Grishchuk B., Yatsyuk V., Baranovskii V. et al.: Pharm. Chem. J., 2016, 50, 534. https://doi.org/10.1007/s11094-016-1484-0
[12] Yatsyuk V., Pokryshko O., Yaniv Z. et al.: Chem. Chem. Technol., 2015, 9, 193. https://doi.org/10.23939/chcht09.02.193
[13] Grishchuk B., Baranovskyi V., Klymnyuk S.: Pharmac. Rev., 2011, 4, 117.