In this study, chitosan-based carrier of red ginger oleoresin was prepared using the emulsion cross-linking technique with sodium tripolyphosphate (TPP) as a cross-linking agent. The effect of chitosan and TPP concentration, as well as pH on the encapsulation efficiency, particle size and characterization of chitosan microcapsule was determined. The antioxidant activity of microcapsules was analyzed. Chitosan microcapsules containing red ginger oleoresin were produced although with non-smooth surfaces.
The Box-Behnken design was used to investigate the effect of three independent variables – time, temperature and solvent-to-solid ratio on the responses of total phenolics, total flavonoids, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and cupric ion reducing antioxidant capacity (CUPRAC) of date fruit methanolic extracts. Response surface analysis showed that the optimal ultrasound extraction parameters that maximized the responses were 30 min, 298 K and 74.4 ml/g. Under optimum conditions, UHPLC-DAD-MS/MS was used to tentatively characterize 11 phenolic compounds.
The diseases of cardiovascular system and oncology are share the first place among all diseases, both in Ukraine and in the world. The problem of arterial thrombosis is one of the important factors that determine the outcome of the diseases.
The chemical composition of essential oil obtained by hydro-distillation with 2.10±0.09 % yield from dried Globularia alypum L. leaves was analyzed by GC-MS. It was determined 60 components representing 99.04 % of total oil. For the evaluation of the mentioned antioxidant activity, three different approaches were performed: the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, b-carotene bleaching (BCB) test systems and ferric reducing/antioxidant power assay (FRAP).The antioxidant was compared with that of synthetic antioxidant ascorbic acid.
A computer-aided prediction of the pharmacological activity of a number of exo-functionalized derivatives of 9,10-anthraquinone with amino acid and thiazole fragments for the search of compounds with antioxidant effect using the program PASS of the web resource Way2Drug was carried out. The obtained results were analyzed for the probability of the mechanism of antioxidant action as a radical scavenger, antihypoxic, oxygen scavenger, radical formation agonist and catalase stimulator.
The paper provides generalized information on the pharmacological properties, chemical
composition and use of primrose (Primula veris) in folk and official medicine. It has been
established that only 9 medicines on the basis of extracts from roots or flowers of the primrose
with a cup used in diseases of the respiratory system are registered in the pharmaceutical
market of Ukraine. In addition, the content of extractives, phenolic compounds, flavonoids,
antioxidant activity of tincture of grass of the primrose of spring is determined.
Досліджено інтенсивність процесів пероксидного окиснення ліпідів (ПОЛ) та
окисної модифікації білків (ОМБ) екстрактів зі шроту лікарських рослин материнки
звичайної (Origanum vulgare L.), моркви дикої (Daucus carota), хмелю звичайного
(Humulus lupulus). Порівняно їхні активності з відомим антиоксидантом – аскорбіновою
кислотою. Встановлено, що за дії всіх досліджуваних екстрактів лікарських речовин
спостерігається гальмування вільнорадикальних процесів за двома показниками
The antioxidant activity of novel N3 and C6 substituted 5,7-dimethyl-3H-thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The correlation analysis between the antioxidant activity and different subsets molecular descriptors was carried out for 19 compounds.
Pure polystyrene films and polystyrene films filled with fullerenes (C60+C70 mix) were fabricated by the solution cast method. Effect of polystyrene/fullerene composite on free-radical processes in blood serum has been investigated in vitro. The parameters of lipid peroxidation in native serum after adding the composite films were determined by a chemiluminescent analysis and spectrophotometry. It was revealed that fullerene-containing nanocomposites can manifest antioxidant activity in blood serum