antioxidant activity

Research on the antioxidant properties of extracts from stemless carline thistle (Carlina acaulis l.), mountain arnica (Arnica montana l.) and pot marigold (Calendula officinalis l.)

The intensity of lipid peroxidation (LPO) and oxidative modification of proteins (OMP) was investigated under the influence of 40% and 70% aqueous-ethanol plant extracts (PE) of the root of Carlina acaulis L., flowers of Arnica montana L. and Calendula officinalis L. on rat liver hepatocytes under conditions of free radical oxidation initiation in vitro.

Design, Synthesis and Biological Activity of the 4-Thioquinoline Derivative

One of the promising areas in the creation of bioregulators is the modeling of compounds that combine several pharmacophores. The design of new highly efficient and low-toxic cytoprotectors is largely based on the derivatives of nitrogen-containing heterocycles, and quinoline plays a significant role among these compounds. The researchers evaluated the toxicity of the tested compounds in silico, in vitro, and in vivo, which allowed determiningseveral factors that affect the level of toxic action of 4-thioquinoline derivatives and the direction of non-toxic substances in this sequence.

Study of alcoholic-water extracts of Thymus Vulgaris obtained by ultrasonic extraction method

Alcohol-water extracts of Thymus vulgaris have obtained by ultrasonic extraction method for different times extraction. The obtained extracts have been tested for the quantitative content of extractive substances, phenolic compounds and flavonoids and for the presence of antioxidant activity. The best studied indicators were found in extract obtained by ultrasound extraction for 40 minutes (content of extractive substances 25 mg / ml, sum of polyphenolic compounds 30 mg / ml, flavonoids content 45 mg / ml).

The Development, Evaluation, and Antioxidant Activity Analysis of Chitosan Microcapsules Containing Red Ginger Oleoresin with Sodium Tripolyphosphate Prepared by Emulsion Cross-linking Technique

In this study, chitosan-based carrier of red ginger oleoresin was prepared using the emulsion cross-linking technique with sodium tripolyphosphate (TPP) as a cross-linking agent. The effect of chitosan and TPP concentration, as well as pH on the encapsulation efficiency, particle size and characterization of chitosan microcapsule was determined. The antioxidant activity of microcapsules was analyzed. Chitosan microcapsules containing red ginger oleoresin were produced although with non-smooth surfaces.

Exploiting Response Surface Methodology (RSM) as a Novel Approach for the Optimization of Phenolic and Antioxidant Activity of Date Palm Fruit

The Box-Behnken design was used to investigate the effect of three independent variables – time, temperature and solvent-to-solid ratio on the responses of total phenolics, total flavonoids, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and cupric ion reducing antioxidant capacity (CUPRAC) of date fruit methanolic extracts. Response surface analysis showed that the optimal ultrasound extraction parameters that maximized the responses were 30 min, 298 K and 74.4 ml/g. Under optimum conditions, UHPLC-DAD-MS/MS was used to tentatively characterize 11 phenolic compounds.

COMPUTER-AIDED PREDICTION IN SEARCH OF NEW ANTIPLATELET AGENTS WITH ANTIOXIDANT EFFECT AMONG SULFUR-CONTAINING DERIVATIVES OF 9,10-ANTHRAQUINONONE

The diseases of cardiovascular system and oncology are share the first place among all diseases, both in Ukraine and in the world. The problem of arterial thrombosis is one of the important factors that determine the outcome of the diseases.

Chemical Composition and Antioxidant Activity of Globularia Alypum L. Leaves Essential Oil from Ain-Defla (Algeria)

The chemical composition of essential oil obtained by hydro-distillation with 2.10±0.09 % yield from dried Globularia alypum L. leaves was analyzed by GC-MS. It was determined 60 components representing 99.04 % of total oil. For the evaluation of the mentioned antioxidant activity, three different approaches were performed: the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, b-carotene bleaching (BCB) test systems and ferric reducing/antioxidant power assay (FRAP).The antioxidant was compared with that of synthetic antioxidant ascorbic acid.

Computer prediction and verification of antioxidative activity of exo-functionalized derivatives of 9,10-antraquinone.

A computer-aided prediction of the pharmacological activity of a number of exo-functionalized derivatives of 9,10-anthraquinone with amino acid and thiazole fragments for the search of compounds with antioxidant effect using the program PASS of the web resource Way2Drug was carried out. The obtained results were analyzed for the probability of the mechanism of antioxidant action as a radical scavenger, antihypoxic, oxygen scavenger, radical formation agonist and catalase stimulator.

SPRING PRECIOUS PRESENTATION – SOURCE OF PHENOL COMPOUNDS WITH ANTIOXIDANT ACTIVITY

The paper provides generalized information on the pharmacological properties, chemical
composition and use of primrose (Primula veris) in folk and official medicine. It has been
established that only 9 medicines on the basis of extracts from roots or flowers of the primrose
with a cup used in diseases of the respiratory system are registered in the pharmaceutical
market of Ukraine. In addition, the content of extractives, phenolic compounds, flavonoids,
antioxidant activity of tincture of grass of the primrose of spring is determined.

Дослідження антиоксидантної активності екстрактів лікарських рослин

Досліджено інтенсивність процесів пероксидного окиснення ліпідів (ПОЛ) та
окисної модифікації білків (ОМБ) екстрактів зі шроту лікарських рослин материнки
звичайної (Origanum vulgare L.), моркви дикої (Daucus carota), хмелю звичайного
(Humulus lupulus). Порівняно їхні активності з відомим антиоксидантом – аскорбіновою
кислотою. Встановлено, що за дії всіх досліджуваних екстрактів лікарських речовин
спостерігається гальмування вільнорадикальних процесів за двома показниками