antioxidant activity

Study on Wheat and Oat Bran Extracts and Their Antioxidant Properties

The article presents the results of a study on aqueous and aqueous-ethanolic extracts derived from the cell wall material of oat and wheat bran, focusing on their content of phenolic compounds, flavonoids, and amino acids. The total phenolic content was assessed spectrophotometrically using the Folin–Ciocalteu method, while the total flavonoid content was determined via an aluminum chloride colorimetric assay. Gallic acid, ferulic acid, and quercetin were also identified in the samples using thin-layer chromatography.

Synthesis, Аntibacterial, Аntifungal, and Antioxidant Activity of New (Benzo)Imidazo[2,1-b][1,3]Thiazine Quaternary Salts

A series of quaternary salts – 1-phenacyl(4-chlorophenacyl)-6-hydroxy-6,7-dihydro-5H-benzo[4,5]imidazo[2,1-b][1,3]thiazinium bromides 4a-f were obtained. Their structures were rigorously proven by the methods of 1H NMR, 13C NMR spectroscopy, and chromatography-mass spectrometry. All obtained compounds were tested in in vitro experiments for antibacterial, antifungal, and antioxidant activity.

Study of antioxidant properties and component composition of cereal crop extracts

The scientific work researched the level of inhibition of Fenton's reagent-initiated lipid peroxidation (LPO) and oxidative modification of proteins (OMP) processes in rat hepatocytes in vitro, as an effect of aqueous, and 40, 70% aqueous-ethanolic extracts of wheat and oat bran. Qualitative reactions were used to assess the total amount of phenolic compounds, especially flavonoids. Thin-layer chromatography (TLC) identified gallic acid, ferulic acid, and quercetin in the samples of the studied objects.

STUDY OF THE EFFECTIVENESS OF BIOSURFACTANT FROM THE CULTURE LIQUID OF BACILLUS SUBTILIS SP. IN THE EXTRACTION OF BIOLOGICALLY ACTIVE SUBSTANCES OF THYMUS SERPYLLUM L.

This work presents a study of the effectiveness of biosurfactant from the culture liquid of Bacillus subtilis sp. on the extraction of biologically active substances in the extraction of thyme Thymus serpyllum L. Ethanol extracts of plant material were obtained by maceration with the addition of biosurfactant in the amount of 0.01% to 0.1% and a corresponding increase in the yield of extractive substances was recorded by the gravimetric method in the range from 2 to 12 %.

Research on the antioxidant properties of extracts from stemless carline thistle (Carlina acaulis l.), mountain arnica (Arnica montana l.) and pot marigold (Calendula officinalis l.)

The intensity of lipid peroxidation (LPO) and oxidative modification of proteins (OMP) was investigated under the influence of 40% and 70% aqueous-ethanol plant extracts (PE) of the root of Carlina acaulis L., flowers of Arnica montana L. and Calendula officinalis L. on rat liver hepatocytes under conditions of free radical oxidation initiation in vitro.

Design, Synthesis and Biological Activity of the 4-Thioquinoline Derivative

One of the promising areas in the creation of bioregulators is the modeling of compounds that combine several pharmacophores. The design of new highly efficient and low-toxic cytoprotectors is largely based on the derivatives of nitrogen-containing heterocycles, and quinoline plays a significant role among these compounds. The researchers evaluated the toxicity of the tested compounds in silico, in vitro, and in vivo, which allowed determiningseveral factors that affect the level of toxic action of 4-thioquinoline derivatives and the direction of non-toxic substances in this sequence.

Study of alcoholic-water extracts of Thymus Vulgaris obtained by ultrasonic extraction method

Alcohol-water extracts of Thymus vulgaris have obtained by ultrasonic extraction method for different times extraction. The obtained extracts have been tested for the quantitative content of extractive substances, phenolic compounds and flavonoids and for the presence of antioxidant activity. The best studied indicators were found in extract obtained by ultrasound extraction for 40 minutes (content of extractive substances 25 mg / ml, sum of polyphenolic compounds 30 mg / ml, flavonoids content 45 mg / ml).

The Development, Evaluation, and Antioxidant Activity Analysis of Chitosan Microcapsules Containing Red Ginger Oleoresin with Sodium Tripolyphosphate Prepared by Emulsion Cross-linking Technique

In this study, chitosan-based carrier of red ginger oleoresin was prepared using the emulsion cross-linking technique with sodium tripolyphosphate (TPP) as a cross-linking agent. The effect of chitosan and TPP concentration, as well as pH on the encapsulation efficiency, particle size and characterization of chitosan microcapsule was determined. The antioxidant activity of microcapsules was analyzed. Chitosan microcapsules containing red ginger oleoresin were produced although with non-smooth surfaces.

Exploiting Response Surface Methodology (RSM) as a Novel Approach for the Optimization of Phenolic and Antioxidant Activity of Date Palm Fruit

The Box-Behnken design was used to investigate the effect of three independent variables – time, temperature and solvent-to-solid ratio on the responses of total phenolics, total flavonoids, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and cupric ion reducing antioxidant capacity (CUPRAC) of date fruit methanolic extracts. Response surface analysis showed that the optimal ultrasound extraction parameters that maximized the responses were 30 min, 298 K and 74.4 ml/g. Under optimum conditions, UHPLC-DAD-MS/MS was used to tentatively characterize 11 phenolic compounds.

COMPUTER-AIDED PREDICTION IN SEARCH OF NEW ANTIPLATELET AGENTS WITH ANTIOXIDANT EFFECT AMONG SULFUR-CONTAINING DERIVATIVES OF 9,10-ANTHRAQUINONONE

The diseases of cardiovascular system and oncology are share the first place among all diseases, both in Ukraine and in the world. The problem of arterial thrombosis is one of the important factors that determine the outcome of the diseases.