antioxidant activity

The antioxidant activity of novel N3 and C6 substituted 5,7-dimethyl-3H-thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The correlation analysis between the antioxidant activity and different subsets molecular descriptors was carried out for 19 compounds.

Pure polystyrene films and polystyrene films filled with fullerenes (C60+C70 mix) were fabricated by the solution cast method. Effect of polystyrene/fullerene composite on free-radical processes in blood serum has been investigated in vitro. The parameters of lipid peroxidation in native serum after adding the composite films were determined by a chemiluminescent analysis and spectrophotometry. It was revealed that fullerene-containing nanocomposites can manifest antioxidant activity in blood serum