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  2. All Volumes and Issues
  3. Volume 17, Number 3, 2023
  4. Salicylaldehydes Derived from 5-Chloromethyl-2-hydroxybenzaldehyde – Synthesis and Reactions

Salicylaldehydes Derived from 5-Chloromethyl-2-hydroxybenzaldehyde – Synthesis and Reactions

JCCT.
2023;
Volume 17, Number 3
: pp. 532 - 541
https://doi.org/10.23939/chcht17.03.532
Authors:
  1. Gheorghe Roman
1
Department of Inorganic Polymers, Petru Poni Institute of Macromolecular Chemistry

A series of salicylaldehydes have been prepared through the replacement of the easily leaving chlorine atom in 5-chloromethyl-2-hydroxybenzaldehyde with various O-, S- or N-nucleophiles. The involvement of a few of these salicylaldehydes in the synthesis of heterocycles such as benzofuran or coumarin, or as substrate in the Petasis borono-Mannich reaction has been explored.

2-hydroxybenzaldehydes
nucleophilic substitution
NMR analysis
heterocyclic synthesis
Petasis reaction
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