Рroduction technology of probiotic preparation based on strains of lactobacillus acidophilus

2023;
: 102-118
1
Lviv Polytechnic National University
2
Lviv Polytechnic National University
3
University of Opole, Poland
4
Lviv Polytechnic National University

Designed and engineered the production of a probiotic preparation based on antibiotic-resistant strains of Lactobacillus acidophilus, which is beneficial to use in conjunction with antibiotic therapy for the treatment of various types of infections to maintain normal intestinal microflora. Provided qualitative characteristics of the raw materials, producer microorganisms, and the final product. On the basis of the material balance of cultivation agreed with the design capacity, technological equipment of appropriate parameters was selected, a block diagram of the technological line and a technological scheme of probiotic production were developed. Implementation of the proposed production of a probiotic preparation based on Lactobacillus acidophilus will allow to expand the range of domestic probiotic dietary supplements.

  1. 1. Hrncir, T. (2022). Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options. Microorganisms, 10(3), 578. https://doi.org/10.3390/microorganisms10030578
    https://doi.org/10.3390/microorganisms10030578
    2. Hill, C., Guarner, F., Reid, G., Gibson, G. R., & Merenstein, D. J. (2014). Pot B6, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol, 11, 506-514. https://doi.org/10.1038/nrgastro.2014.66
    https://doi.org/10.1038/nrgastro.2014.66
    3. Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., Verbeke, K., & Reid, G. (2017). Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology, 14(8), 491-502. https://doi.org/10.1038/nrgastro.2017.75
    https://doi.org/10.1038/nrgastro.2017.75
    4. Office of Dietary Supplements - Probiotics. Office of Dietary Supplements (ODS). https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/.
    5. Wilkins, T. (2017, August 1). Probiotics for Gastrointestinal Conditions: A Summary of the Evidence. Am Fam Physician, 96(3), 170-178. https://www.aafp.org/pubs/afp/issues/2017/0801/p170.html.
    6. Pharmacy 911 - Online health supermarket. Pharmacy 911 - Online health supermarket. https://apteka911.ua/ua/shop/dietichna-dobavka-dlya-regulyuvannya-mikrof...
    7. Pharmacy 911 - Online health supermarket. Pharmacy 911 - Online health supermarket. https://apteka911.ua/ua/shop/probiotiks-imuno-nova-formula-kaps-20-solut...
    8. Guerrero, C., & Illanes, A. (2016). Enzymatic production of other lactose-derived prebiotic candidates. In Lactose-Derived Prebiotics: A Process Perspective (pp. 229-259). Elsevier Inc. https://doi.org/10.1016/b978-0-12-802724-0.00006-8
    https://doi.org/10.1016/B978-0-12-802724-0.00006-8
    9. Lactitol. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Lactitol#section=Structures.
    10. Ingold, C. J. (2023, February 11). Simethicone. StatPearls - NCBI Bookshelf . https://www.ncbi.nlm.nih.gov/books/NBK555997/
    11. Banwo, K., Adesina, T., Aribisala, O., & Falade, T. D. (2023). Detoxification of Aflatoxins in Fermented Cereal Gruel (Ogi) by Probiotic Lactic Acid Bacteria and Yeasts with Differences in Amino Acid Profiles. Toxins, 15(3), 210. https://doi.org/10.3390/toxins15030210
    https://doi.org/10.3390/toxins15030210
    12. Wehrli, C. (1993, January 26). US5410056A - Method for the production of folic acid - Google Patents. https://patents.google.com/patent/US5410056A/en.
    13. Folic Acid. (n.d.-a). PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Folic-Acid.
    14. Office of Dietary Supplements - Vitamin B12. (n.d.). Office of Dietary Supplements (ODS). https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/.
    15. Calvillo, Á., Pellicer, T., Carnicer, M., & Planas, A. (2022). Bioprocess Strategies for Vitamin B12 Production by Microbial Fermentation and Its Market Applications. Bioengineering, 9(8), 365. https://doi.org/10.3390/bioengineering9080365
    https://doi.org/10.3390/bioengineering9080365
    16. 赵富贵. (2006, July 27). CN1887845A - Granular sodium benzoate and its production process - Google Patents. https://patents.google.com/patent/CN1887845A/en.
    17. Bull, M., Plummer, S., Marchesi, J., & Mahenthiralingam, E. (2013). The life history of Lactobacillus acidophilus as a probiotic: a tale of revisionary taxonomy, misidentification and commercial success. FEMS microbiology letters, 349(2), 77-87. https://doi.org/10.1111/1574-6968.12293
    https://doi.org/10.1111/1574-6968.12293
    18. Sapkota, A. (2021). Lactobacillus acidophilus-An Overview - Microbe Notes. https://microbenotes.com/lactobacillus-acidophilus/.
    19. Oladipo, I. C., Anwooko, D. O., Daramola, D. I., Babalola, F. B., Abidoye, G. T., Olawale, O. D., ... & Olanbiwoninu, A. A. (2016). Bioprotective potential of bacteriocins from some Lactobacillus species isolated from foods. The Journal of Microbiology, Biotechnology and Food Sciences, 6(3), 900. https://doi.org/10.15414/jmbfs.2016/17.6.3.900-904
    https://doi.org/10.15414/jmbfs.2016/17.6.3.900-904
    20. Taye, Y., Degu, T., Fesseha, H., & Mathewos, M. (2021). Isolation and identification of lactic acid bacteria from cow milk and milk products. The Scientific World Journal, 2021. https://doi.org/10.1155/2021/4697445
    https://doi.org/10.1155/2021/4697445
    21. Islam, R., Hossain, M. N., Alam, M. K., Uddin, M. E., Rony, M. H., Imran, M. A. S., & Alam, M. F. (2020). Antibacterial activity of lactic acid bacteria and extraction of bacteriocin protein. Advances in Bioscience and Biotechnology, 11(02), 49-59. https://doi.org/10.4236/abb.2020.112004
    https://doi.org/10.4236/abb.2020.112004
    22. Lactophore. Tabletki.ua. https://tabletki.ua/uk/Лактофор-10/1007446/
    23. 翟光喜. (2015, January 13). CN104610745A - Preparation method for simethicone - Google Patents. https://patents.google.com/patent/CN104610745A/en.
    24. Hayek, S. A., Gyawali, R., Aljaloud, S. O., Krastanov, A., & Ibrahim, S. A. (2019). Cultivation media for lactic acid bacteria used in dairy products. Journal of Dairy Research, 86(4), 490-502. https://doi.org/10.1017/s002202991900075x
    https://doi.org/10.1017/S002202991900075X
    25. Federica.Ferrari. (2022). What is Rye Flour and How to Bake With It? https://www.finedininglovers.com/article/rye-flour-benefits-use.
    26. Sydorov YU. I., Vlyazlo R. Y., Novikov V. s. (2008). Protsesy ta aparaty mikrobiolohichnoyi ta farmatsevtychnoyi promyslovosti. Lʹviv: Intelekt-Zakhid.