As a part of our continuous research on potential antihypertensive agents among morpholine and piperidine derivatives, 10 novel target compounds containing 1,2,4-triazole and morpholine or piperidine moieties have been designed and synthesized, and the docking studies have been conducted in order to find biologically active substances with the antihypertensive activity. The in silico studies have shown that all compounds synthesized are promising angiotensin converting enzyme inhibitors and belong to the toxicity class 4 and 5 according to the classification of chemicals by the OECD project.
- Kang D., Fang Z., Huang B. et al.: Chem. Biol. Drug Design, 2015, 86, 568. https://doi.org/10.1111/cbdd.12520
- Drapak І., Zimenkovsky B., Perekhoda L. et al.: Pharmacia, 2019, 66, 33. https://doi.org/10.3897/pharmacia.66.e35083
- Ueda Y., Timothy P., Wang I. et al.: Pat. US 8461333 B2, Publ. Jun. 11, 2013.
- Yradjan M., Yradjan N., Paronykjan R., Stepanjan H.: Khimiko-Farmacevt. Zh., 2010, 44, 11.
- Klen E., Makarova N., Chalyullyn F. et al.: Bashkirsky Khim. Zh., 2008, 15, 112.
- Jakhmola V., Jawla S., Mishra R.: Acta Sci. Pharm. Sci., 2018, 2, 02.
- Al-Ghorbani M., Begum B. et al.: J. Chem. Pharm. Res., 2015, 8, 611. https://doi.org/10.5958/0974-360X.2015.00100.6
- Kourounakis A., Xanthopoulos D., Tzara A.: Med. Res. Rev., 2020, 40, 709. https://doi.org/10.1002/med.21634
- Yan X., Wang Z., Qi P. et al.: Eur. J. Med. Chem., 2019, 177, 425. https://doi.org/10.1016/j.ejmech.2019.05.056
- Ladopoulou E., Matralis A., Nikitakis A., Kourounakis A.: Bioorg. Med. Chem., 2015, 23, 7015. https://doi.org/10.1016/j.bmc.2015.09.034
- Mytnyk Z., Kolesnyk Ju.: Zaporozhsky Med. Zh., 2010, 12, 79.
- Bhat M., Al-Omar M., Ghabbour H., Naglah A.: Molecules, 2018, 23, 1559. https://doi.org/10.3390/molecules23071559
- Manjusha R., Begum S., Begum A., Bharathi K.: Asian J. Pharm. Clinical Res., 2018, 11, 66. https://doi.org/10.3390/molecules23071559
- Kaplaushenko A.: Naukovyi Zh. MOZ Ukrainy, 2013, 3, 152.
- Sahu N., Sahu J., Kaushik A.: Curr. Res. Pharm. Sci., 2013, 3, 108.
- Malani A., Makwana A., Makwana H.: Moroccan J. Chem., 2017, 5, 41.
- Liu J., Liu Q., Yang X. et al.: Bioorgan. Med. Chem., 2013, 21, 7742. https://doi.org/10.1016/j.bmc.2013.10.017
- Zhou C.-H., Wang Y.: Current Medicinal Chemistry, 2012, 19, 239. https://doi.org/10.2174/092986712803414213
- http://accelrys.com/
- http://www.way2drug.com/gusar/acutoxpredict.html
- Drapak I., Suleiman M., Protopopov M. et al.: Res. J. Pharm. Technol., 2019, 12, 4889. https://doi.org/10.5958/0974-360X.2019.00846.1
- Anthony C., Corradi H., Schwager S. et al.: J. Biol. Chem., 2010, 285, 35685. https://doi.org/10.1074/jbc.M110.167866
- Kramer G., Mohd A., Schwager S. et al.: ACS Med. Chem. Lett., 2014, 5, 346. https://doi.org/10.1021/ml4004588
- http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpa...