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  2. All Volumes and Issues
  3. Volume 14, Number 3, 2020
  4. Study of Biodegradation, Biocompatibility and Bactericidal Activity of Film Materials with Tiamulin Fumarate Based on Polyurethaneurea

Study of Biodegradation, Biocompatibility and Bactericidal Activity of Film Materials with Tiamulin Fumarate Based on Polyurethaneurea

JCCT.
2020;
Volume 14, Number 3
: pp. 318 - 326
https://doi.org/10.23939/chcht14.03.318
Authors:
  1. Tetiana Vislohuzova
  2. Rita Rozhnova
  3. Natalia Galatenko
  4. Larysa Narazhayko
  5. Ada Rudenko
1
Institute of Macromolecular Chemistry of the NAS of Ukraine
2
nstitute of Macromolecular Chemistry of the NAS of Ukraine
3
Institute of Macromolecular Chemistry of the NAS of Ukraine
4
Institute of Macromolecular Chemistry of the NAS of Ukraine
5
Institute of Urology of the National Academy of Medical Sciences of Ukraine

The influence of the model biological medium 199 on the structure and properties of film materials with tiamulin fumarate based on polyurethaneurea containing in its structure the hydrophilic fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alcohol has been investigated. According to IR spectroscopy, under the influence of the biological medium 199 there are processes of biodegradation of polymer materials which are accompanied by a decrease in the intensity of the absorption band νС=О of vinylpyrrolidone ring. It is established that the introduction of tiamulin fumarate into polyurethaneurea facilitates their biodegradation, as evidenced by a decrease of the tensile strength (1.28–2.38 times) and a relative elongation at break (1.36–1.82 times) after incubation in the biological medium 199 by physico-mechanical tests. The tissue culture method has established the biocompatibility of film materials with tiamulin fumarate. According to the results of microbiological studies, bactericidal properties were observed in relation to the bacteria Staphylococcus aureus and Escherichia coli. It allows using them for production of drainage in abdominal surgery.

polyurethaneurea
tiamulin fumarate
N-vinylpyrrolidone
copolymer
vinyl acetate
vinyl alcohol
model biological medium 199
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