Influence of Ni (II), Cu (II) and Zn (II) complex formation on interaction with model cellular membranes


Liya Khmars’ka, Kostyantyn Kylyvnyk and Olexandr Shtemenko

Influence of complex compounds of nickel (II), copper (II) and zinc (II) with nitrogen containing ligands on conductivity of bilayer lipid membranes (BLMs) was studied. The role of conditions (pH, metal and ligand concentration) on complex formation and interaction with BLMs was evaluated. Composition and form of complex ions in solution which maximally change conductivity have been calculated. Relationship between the complex form predominant in the solution and BLM conductivity indicated that complex ions influence mostly depended on surrounding ligands and did not depend on the nature of the central atom. Permeability coefficients for complex ions which maximally changed BLM conductivity were calculated.

[1] Rosenberg B., VanCamp L. and Trosko J.: Nature, 1969, 222, 385.
[2]. Koepf-Maier P. and Koepf H.: Chem. Rev., 1987, 87, 1137.
[3] Bakhtian R. and Ochiai E.: General Pharmacology, 1999, 32, 525.
[4] Kriss E., Volchenskova I., Grigor’eva A. et al.: Koordinatsionnye Soedineniya Metalov v Meditsine. Naykova dumka, Kiyv 1986. 
[5] Tien H. and Ottova-Leitmannova A.: Planar Lipid Bilayers (Blms) and their Applications. Elsevier Science Ltd. 2003. 
[6] Folch J., Lees M. and Stanley G.: J. Biolog. Chem., 1957, 226, 497.
[7] Mueller P., Rudin P., Tien M. and Wescit W.: [in:] Danielli J., Pankhurst K. and Riddiford A. (Eds.), Recent Progress in Surface Science. Academic Press, N.Y.-London 1964.
[8] Tien Ti H.: J. Phys. Chem., 1984, 88, 3172.
[9] Kylyvnyk K. and Ksenzhek O.: Voprosy Khim. i Khim. Technol., 2003, 5, 124.
[10] Cieslak-Golonka M., Bartecki A. and Jezierska J.: Polyhedron, 1991, 10, 2179.
[11] Bjerruum J.: Metal Ammine Formation in Aqueous Solution. Theory of the reversible step reactions. P. Hasse & Son, Copenhagen 1957.
[12] Ahmad N. and Rahman S.: Zeitschrift für anorganische und allgemeine Chemie, 1964, 330, 210.
[13] Kirschenbaum L. and Kustin K.: J. Chem. Soc. A, 1970, 1, 684.
[14] Cabani S., Moretti G and Scrocco E.: J. Chem. Soc., 1962, 17, 88.
[15] Cabani S. and Landucci M.: ibid, 278.
[17] Alderighi L., Gans P., Ienco A., et al.: Coordination Chem. Rev., 1999, 184, 311.
[18] Bjerrum J., Schwarzenbach G. and Sillen L.: Stability Constants of Metal-Ion Complexes: Part I Organic Ligands. Burlington House, Chemical Society: London 1975.
[19] Lide D. (Ed.): Handbook of Chemistry and Physics (84th edn.), CRC Press LLC 2004.
[20] Omel’chenko O.: Itogi Nauki i Tekhniki,1991, 29, 10. 
[21] Khmars’ka L., Kylyvnyk K. and Shtemenko O.: Voprosy Khim. i Khim. Technol., 2007, 4, 41.
[22] Brahm J., Funder J. and Gasbjerg P.: Eleventh School on Biophysics of Membrane Transport, Poland 1992, 1, 9.
[23] Leo A., Hansch C. and Elkins D.: Chem. Rev., 1971, 71, 526. 
[24] Dataset of LogP values C – logP: BioByte Corp., Claremont, CA, USA.