RELEASE KINETICS OF ANESTHETIC AGENTS FROM GELATIN–ALGINATE HYDROGELS
This study examines the kinetic profiles of lidocaine hydrochloride, novocaine hydrochloride, and diclofenac sodium release from gelatin–alginate hydrogels crosslinked with poly(ethylene glycol) diglycidyl ether. Drug release was evaluated in phosphate-buffered saline (PBS) and in PBS supplemented with a proteolytic enzyme using a Franz diffusion cell. The experimental data were fitted to zero-order and first-order kinetic models, as well as the Higuchi, Hixson–Crowell, and Korsmeyer–Peppas models.