Development of the powder composition with thiosulfonate component and study of its antimicrobial effect

The paper presents the results of research on the development of a potential drug that consists of S-ethyl ester of 4-acetylaminobenzene sulfonic acid and excipients in the powder dosage form for topical use. The powder composition was substantiated on the basis of microbiological studies of the introduced compound and the dosage form based on it. The rational content of the compound as a biologically active substance in the powder was established. The optimal composition of excipients was selected.

Obtaining and Determining Antiviral and Antibacterial Activity of S-Esters of 4-R-Aminobenzenethiosulfonic Acid

A number of S-esters of 4-R-aminobenzene¬thiosulfonic acids were synthesized via alkylation of the sodium salt of 4-acetylaminobenzenethiosulfonic acid with various alkylating agents and acylation of the corresponding esters of 4-aminobenzenethiosulfonic acid with metha-cryloyl chloride. For obtaining S-methyl 4-(acetyla-mino)benzenesulfonothioate, it was developed a synthetic technique corresponding to the basic principles of "green chemistry". The degree of compound cytotox-icity was measured by determining A-549 cell growth using colorimetric method.

Тhe influence of thiosulfic acid derivatives on the morphological properties of loach embryos at the initial stages of development

By means of morphological studies, it was established that the influence of thiosulfonate solutions of different structure doesn’t show an inhibition of blastomere division and germ layer formation of the freshwater bony fish, namely weatherfish (MisgurnusfossіlisL).


Derivatives of pyrimidine are the object of interest to researchers working in the field of medical chemistry. However, despite the rich history of searching for potential biologically active agents among substances containing this heterocyclic fragment, their potential is still unused. There are vitamins, vasodilators, antidiabetic, antibacterial, antimalarial substances among the derivatives of pyrimidine. A special group among the biologically active compounds is sulfurcontaining derivatives of pyrimidine (sulfides, salts of sulfonic acids, sulfonamides, sulfenamides, disulfides).


Cyanuric chloride is a valuable starting agent for the direct obtaining of highly structured molecules. The substitution of chlorine atoms in the molecule of cyanuric chloride by various pharmacophores’ fragments provides the obtaining a number of 1,3,5-triazine derivatives, among which the promising biologically active substances showing antimicrobial, anticancer, antimalarial and antiviral activity were detected.

Дослідження взаємодії солей тіосульфокислот з 2,3-дихлор-1,4-нафтохіноном

The nucleophilic substitution of halogens in 2,3-dichlor-1,4-naphtoquinone with salts of aliphatic, aromatic and heterocyclic thiosulfonic acids have been researched. 
Досліджено нуклеофільне заміщення галогенів у 2,3-дихлор-1,4-нафтохіноні солями аліфатичних, ароматичних та гетероциклічних тіосульфокислот.