Homeopathic medicine based on Carapichea Ipecacuanha for the treatment of alcoholism

Based on the results of the SWOT-analysis, the prospects and strategy for the development of a homeopathic medicinal product based on ipecacuanha are substantiated. It was found that there is only one domestic complex drug on the pharmaceutical market. It is shown that reduction of the cost and improvement of the quality of the starting material is possible with the use of biotechnological methods. Ultrasonic filtration is proposed to obtain the matrix tincture. It has been established that a homeopathic remedy with ipecacuanha can be a means of additional therapy at the stage of detoxification and the formation of patient's alcohol aversion. The necessity of additional research and improvement of quality control methods is proved.

1. Mondal, S., & Moktan, S. (2020). A Paradoxically Significant Medicinal Plant Carapichea ipecacuanha: A Review. Indian Journal of Pharmaceutical Education and Research, 54(2), 56-66.
https://doi.org/10.5530/ijper.54.2s.61
2. Simon S.K. (1918). Comparative Value of Ipecac and its Alkaloids in Treatment of Intestinal Endamebiasis. JAMA, 71(25), 2042-2046. DOI:10.1001/jama.1918.02600510010003
https://doi.org/10.1001/jama.1918.02600510010003
3. Saisai Tian, Yanan Li, Jia Xu, Lijun Zhang, Jinbo Zhang, Jinyuan Lu, Xike Xu, Xin Luan, Jing Zhao, & Weidong Zhang. (2023). COIMMR: a computational framework to reveal the contribution of herbal ingredients against human cancer via immune microenvironment and metabolic reprogramming, Briefings in Bioinformatics, 24(6), 346. DOI:10.1093/bib/bbad346
https://doi.org/10.1093/bib/bbad346
4. Patel, Kanika, & Patel, Dinesh K. (2021). Health Benefits of Ipecac and Cephaeline: Their Potential in Health Promotion and Disease Prevention. Current Bioactive Compounds, 17(3), 206-213. DOI:10.2174/1573407216999200609130841
https://doi.org/10.2174/1573407216999200609130841
5. Benzoni, T., & Gibson, J. Ipecac. National Library of Medicine. The National Center for Biotechnology Information. (2024 Jan. 21) Available from: https://www.ncbi.nlm.nih.gov/books/NBK448075/
6. Voß, H.W., Michalsen, A., & Brünjes, R. (2018). Efficacy and tolerability of a complex homeopathic drug in children suffering from dry cough-A double-blind, placebo-controlled, clinical trial. Drug Res (Stuttg), 68(8), 444-449. DOI: 10.1055/s-0043-124179.
https://doi.org/10.1055/s-0043-124179
7. Three Uses for Homeopathic Ipecacuanha (2024 Jan. 15) Available from: https://boironusa.com/ipecacuanha-for-nausea-vomiting/
8. Rogers, J. (1997). Homoeopathy and the treatment of alcohol-related problems. Complement Ther Nurs Midwifery. 3(1), 21-8. DOI: 10.1016/s1353-6117(97)80030-3.
https://doi.org/10.1016/S1353-6117(97)80030-3
9. Das, Abhinandan & Sarkar, Tanmay & Das, Shimul & Sabud, Abhisake. (2023). Efficacy of Homoeopathic Medicine in the Treatment of Osteoarthritis: A Systematic Review. AYUSHDHARA, 10, 116-126. DOI: 10.33545/26164485.2023.v7.i3d.911.
https://doi.org/10.33545/26164485.2023.v7.i3d.911
10. Manchanda, Raj K.; Nair, K. R. Janardanan; Varanasi, Roja; Oberai, Praveen; Bhuvaneswari, R.; Bhalerao, Rupali; Gnnanaprakasham, M.; Padmanabhan, Maya; Siddiqui, V. A. (2016) A randomized comparative trial in the management of Alcohol Dependence: Individualized Homoeopathy versus standard Allopathic Treatment. Indian Journal of Research in Homoeopathy URI: http://aohindia.in:8080/xmlui/handle/123456789/1688
11. Tanveer, Akbar, Khan.  (2023). Efficacy of homeopathic treatment in the wives of alcoholic addict male patients. NeuroQuantology; Bornova Izmir, 21(1), 100-116. DOI:10.48047/nq.2023.21.01.NQ20006
12. Habs, M., & Koller, M. (2021). Material Risks of Homeopathic Medicinal Products: Regulatory Frameworks, Results of Preclinical Toxicology, and Clinical Meta-Analyses and Their Implications. Complement Med Res., 28(1), 64-84. DOI:10.1159/000507952.
https://doi.org/10.1159/000507952
13. Stub, T., Kristoffersen, A.E., Alræk, T., Musial, F., &Steinsbekk, A. (2015). Risk in homeopathy: Classification of adverse events and homeopathic aggravations - A cross sectional study among Norwegian homeopath patients. Complement Ther Med., 23(4), 535-43. DOI: 10.1016/j.ctim.2015.06.004.
https://doi.org/10.1016/j.ctim.2015.06.004
14. de-Madaria, E., Mira, J.J., Carrillo, I., et al. (2022). The present and future of gastroenterology and hepatology: an international SWOT analysis (the GASTROSWOT project). The lancet. Gastroenterology & Hepatology,7(5), 485-494. DOI: 10.1016/s2468-1253(21)00442-8. PMID: 35247318.
https://doi.org/10.1016/S2468-1253(21)00442-8
15. Antoniadou, M.; Kanellopoulou, A. (2023). Educational Approach: Leveraging SWOT Analysis for Entrepreneurial Success in Senior Dental Students. Preprints 2023121713. https://doi.org/10.20944/preprints202312.1713.v1
https://doi.org/10.20944/preprints202312.1713.v1
16. Law of Ukraine "Pro likarski zasoby" on July 28, 2022 № 2469-IX. (2022). https://zakon.rada.gov.ua/laws/show/2469-20#Text
17. State Pharmacopoeia of Ukraine, Addition 2 (2.2) (2018). Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines, 336.
18. O'Connor, Joseph T. (1890). The American homoeopathic pharmacopoeia. New York: Boericke & Tafel, 4th. ed. / rev. and augm. by Joseph T. O'Connor, 521p. NLM Unique ID: 101313392 https://collections.nlm.nih.gov/catalog/nlm:nlmuid-101313392-bk
19. State Pharmacopoeia of Ukraine, Addition 2 (2.4) (2020). Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines, 600.
20. Tanveer, A. K. (2023). Efficacy of homeopathic treatment in the wives of alcoholic addict male patients, NeuroQuantology, 21(1), 100-116. DOI: 10.48047/nq.2023.21.01.NQ20006
21. Sánchez, R. A. O. (2004). Ipecac [Psychotria ipecacuanha (Brotero) Stokes] root: A non-timber forest product cultivated within the Huetar Norte forest, Costa Rica. In M. N. Alexiades & P. Shanley (Eds.), Forest Products, Livelihoods and Conservation: Case Studies of Non-Timber Forest Product Systems (pp. 247-262). Center for International Forestry Research. http://www.jstor.org/stable/resrep02086.18
22. Rout, G.R., Samantaray, S. & Das, P. (2000). In vitro somatic embryogenesis from callus cultures of Cephaelis ipecacuanha A. Richard, Scientia Horticulturae, 86(1), 71-79. DOI:10.1016/S0304-4238(00)00130-8
https://doi.org/10.1016/S0304-4238(00)00130-8
23. Yoshimatsu, Kayo. (2008). Tissue culture of medicinal plants: Micropropagation, transformation and production of useful secondary metabolites, Studies in Natural Products Chemistry, Elsevier, 34, 647-752. DOI:10.1016/S1572-5995(08)80033-6.
https://doi.org/10.1016/S1572-5995(08)80033-6
24. Okazaki, K., Koike, I. & Kera, S. (2022). Gene expression profiling before and after internode culture for adventitious shoot formation in ipecac. BMC Plant Biol 22, 361. DOI:10.1186/s12870-022-03756-w
https://doi.org/10.1186/s12870-022-03756-w
25. Song Jian, Pei Caiyun, Wang Zongquan, Han Guiru, Jia Yongxin (2012) Preparation method for extracting and separating emetini hydrochloridium and cephaeline hydrochloride from ipecace. (China patent CN102633793B) https://patents.google.com/patent/CN102633793B/en
26. Varsha, Umesh & Ghate, Varsha & Umesh, Shivajirao & Sharir, Kriya. (2018). Review of homoeopathic pharmacy in the light of quality control. World journal of pharmacy and pharmaceutical sciences, 7(1), 294-298. DOI:10.20959/wjpps20181-10
27. Sehner, S.-M. & Melzig, M.F. (2022). Fluorometric quantification of alkaloids in the homeopathic mother tinctures of Vinca minor L. and Fumaria officinalis L. International Journal of Pharmaceutical Sciences, 77(1), 2-5. DOI:10.1691/ph.2022.1135
28. Philips, C.A., Augustine P., Paramaguru, R. & Ahamed, R. (2019). Homeopathy-medicine induced severe alcoholic hepatitis. BMJ Case Rep. 12(5). DOI:10.1136/bcr-2019-229627.
https://doi.org/10.1136/bcr-2019-229627