The study is devoted to the development and evaluation of alginate hydrogel plates modified with tea tree and rosemary essential oils as a potential wound treatment material. The introduction of these oils into the hydrogel has led to a significant increase in the antibacterial properties of the hydrogel, making it effective against pathogens. Importantly, the inclusion of essential oils does not impair the physical, mechanical, and operational characteristics of hydrogel plates. The obtained results confirm the prospects of their introduction into medical practice for the effective treatment of wounds.
- Bayraktar, S., Copur, B., Gunes, E., Uysal, A., Okudan A. (2025). Antimicrobial activity and characterization of PVA/CMC hydrogels prepared with essential oil. Journal of Thermoplastic Composite Materials, https://doi:10.1177/08927057251344282 https://doi.org/10.1177/08927057251344282
- Parın, F.N., El-Ghazali, S., Yeşilyurt, A., Parın, U., Ullah, A., Khatri, M., Kim, I.S. (2023). PVA/Inulin-Based Sustainable Films Reinforced with Pickering Emulsion of Niaouli Essential Oil for Potential Wound Healing Applications. Polymers, 15(4), 1002. https://doi.org/10.3390/polym15041002 https://doi.org/10.3390/polym15041002
- Dubey, S., Sharma, R., Mody, N., & Vyas, S. P. (2018). Polymeric hydrogel: A flexible carrier system for drug delivery. In Functional biopolymers Springer, 141-184. https://doi.org/10.1007/978-981-10-6083-0 https://doi.org/10.1007/978-981-10-6083-0
- Pauli, Alexander. (2001). Antimicrobial properties of essential oil constituents. International Journal of Aromatherapy, 11, 126-133. https://doi.org/10.1016/S0962-4562(01)80048-5 https://doi.org/10.1016/S0962-4562(01)80048-5
- Tohfa Siddiqui, Mohammad Umar Khan, Vikram Sharma, Komal Gupta. (2024). Terpenoids in essential oils: Chemistry, classification, and potential impact on human health and industry. Phytomedicine Plus, 4(2), 100549. https://doi.org/10.1016/j.phyplu.2024.100549. https://doi.org/10.1016/j.phyplu.2024.100549
- Farooqui, Heena. (2021). A Review on Role of Essential Oil as Penetration Enhancer in Transdermal Drug Delivery System. Systematic Reviews in Pharmacy, 12, 439-444. https://doi.org/10.51268/srp.2021.8.4.
- Pinto, E.P., Menezes, R.P., Tavares, W.d.S., Ferreira, A.M., de Sousa, F.F.O., da Silva, G.A., Zamora, R.R., Araújo, R.S., de Souza, T.M. (2023). Copaiba essential oil loaded-nanocapsules film as a potential candidate for treating skin disorders: Preparation, characterization, and antibacterial properties. Int. J. Pharm., 633, 122608. https://doi: 10.1016/j.ijpharm.2023.122608 https://doi.org/10.1016/j.ijpharm.2023.122608
- Barradas, T.N., Senna, J.P., Cardoso, S.A., Nicoli, S., Padula, C., Santi, P., Rossi, F., de Holanda E., Silva, K.G., Mansur, C.R.E. (2017). Hydrogel-thickened nanoemulsions based on essential oils for topical delivery of psoralen: Permeation and stability studies. Eur. J. Pharm. Biopharm. 116, 38-50. https://doi: 10.1016/j.ejpb.2016.11.018 https://doi.org/10.1016/j.ejpb.2016.11.018
- Touati, A., Mairi, A., Ibrahim, N.A., Idres, T. (2025). Essential Oils for Biofilm Control: Mechanisms, Synergies, and Translational Challenges in the Era of Antimicrobial Resistance. Antibiotics, 14(5), 503. https://doi.org/10.3390/antibiotics14050503 https://doi.org/10.3390/antibiotics14050503
- Khwaza, V., Aderibigbe, B.A. (2025). Antibacterial Activity of Selected Essential Oil Components and Their Derivatives: A Review. Antibiotics, 14(1), 68. https://doi.org/10.3390/antibiotics14010068 https://doi.org/10.3390/antibiotics14010068
- Bordenyuk, O.Y., Kapatsila, S.М., Tsykunkov, S.S., Nadashkevych, Z.Ya., Fihurka, N.V., Samaryk, V.Ya. (2024). Synthesis and study of the properties of crosslinked polyacrylic acid copolymers. Chemistry, Technology and Application of Substances, 7, 1, 196-201. https://doi.org/10.23939/ctas2024.01.196 https://doi.org/10.23939/ctas2024.01.196
- Kozak, M., Stasiuk, A., Vlizlo, V., Ostapiv, D., Bodnar, Y., Kuz'mina, N., Figurka, N., Nosova, N., Ostapiv, R., Kotsumbas, I. (2023). Polyphosphate Ester-Type Transporters Improve Antimicrobial Properties of Oxytetracycline. Antibiotics, 12, 616. https://doi.org/10.3390/antibiotics12030616 https://doi.org/10.3390/antibiotics12030616
- Puvača, N., Milenković, J., Galonja Coghill, T., Bursić, V., Petrović, A., Tanasković, S., Pelić, M., Ljubojević Pelić, D., Miljković T. (2021). Antimicrobial Activity of Selected Essential Oils against Selected Pathogenic Bacteria: In Vitro Study. Antibiotics (Basel), 10(5), 546. https://doi: 10.3390/antibiotics10050546 https://doi.org/10.3390/antibiotics10050546
- Hudecová, P., Koščová, J., Hajdučková, V, Király, J., Horňak, P. (2024). Antibacterial and Antibiofilm Activity of Essential Oils Against Aeromonas spp. Isolated from Rainbow Trout. Animals (Basel), 14(22), 3202. https://doi: 10.3390/ani14223202 https://doi.org/10.3390/ani14223202
- Ghasemzadeh, Rahbardar M., Hosseinzadeh, H. (2020). Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. Iran J Basic Med Sci., 23(9), 1100-1112. https://doi: 10.22038/ijbms.2020.45269.10541.
- Naderali, E., Nikbakht, F., Ofogh, S.N., Rasoolijazi, H. (2018). The role of rosemary extract in degeneration of hippocampal neurons induced by kainic acid in the rat: A behavioral and histochemical approach. J Integr Neurosci., 17, 31-43. https://doi: 10.31083/JIN-170035. https://doi.org/10.31083/JIN-170035
- Javed, S., Mangla, B., Salawi, A., Sultan, M.H., Almoshari, Y., Ahsan, W. . (2024). Essential Oils as Dermocosmetic Agents, Their Mechanism of Action and Nanolipidic Formulations for Maximized Skincare. Cosmetics, 11(6), 210. https://doi.org/10.3390/cosmetics11060210 https://doi.org/10.3390/cosmetics11060210
- de Sousa, D.P., Damasceno, R.O.S, Amorati, R., Elshabrawy, H.A., de Castro, R.D, Bezerra, D.P., Nunes, V.R.V., Gomes, R.C., Lima, T.C. (2023). Essential Oils: Chemistry and Pharmacological Activities. Biomolecules, 13(7), 1144. https://doi.org/10.3390/biom13071144 https://doi.org/10.3390/biom13071144
- Zhao, Q., Zhu, L., Wang, S., Gao, Y., Jin, F. (2023). Molecular mechanism of the anti-inflammatory effects of plant essential oils: A systematic review. J. Ethnopharmacol., 301, 115829. https://doi.org/10.1016/j.jep.2022.115829 https://doi.org/10.1016/j.jep.2022.115829