Synthesis of 2-Oxo(thio)-N,4-diaryl-1,2,3,4-tetrahydropyrimidine-5-carbothioamides

2016;
: pp. 279 – 283
Автори: 
Olena Maiboroda and Nathaliia Simurova

National University of Food Technologies, 68, Volodymyrska St., 01601 Kyiv-33, Ukraine

It was found that 2-acylthioacetamides enter Biginelli reaction with aromatic aldehydes and urea /thiourea forming 2-oxo(thio)-N,4-diaryl-1,2,3,4-tetrahydropyrimidine-5-carbothioamides. Under the influence of K3[Fe(CN)6] in alkaline environment, the expected 2-oxo(thio)-N,4-diaryl-5-(benzothiazole-2'-yl)-1,2,3,4-tetrahydropyrimidines were not been received while 2-oxo(thio)-N,4-diaryl-1,2,3,4-tetrahydropyrimidine-5-carbamides were the products of interaction.

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