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  3. Volume 14, Number 2, 2020
  4. Preparation and Characterization of Molecular Imprinted Polymer for the Selective Recognition of Serotonin

Preparation and Characterization of Molecular Imprinted Polymer for the Selective Recognition of Serotonin

JCCT.
2020;
Volume 14, Number 2
: pp. 195 - 204
https://doi.org/10.23939/chcht14.02.195
Authors:
  1. Ceylan Hepokur
  2. H. Nursevin Öztop
  3. Dursun Saraydin
1
Sivas Cumhuriyet University, Sivas, Turkey
2
Sivas Cumhuriyet University, Sivas, Turkey
3
Sivas Cumhuriyet University, Sivas, Turkey

Molecularly imprinted polymers (MIPs) were prepared for highly selective recognition of serotonin. Acrylamide, methacrylic acid and methacrylamide were selected as the monomers for the production of MIPs. Functional monomers were polymerized with ethylene glycol dimethacrylate, 1,4-butanediol diacrylate, and trimethylpropane triacrylate with serotonin (MIP-EGDMA, MIP-BUT and MIP-TMT). Serotonin was removed from MIP by the mixture of methanol/acetic acid (4:1). Non-imprinted polymers (NIPs) were synthesized without serotonin (NIP-EGDMA, NIP-BUT and NIP-TMT). For the characterization of synthesized polymers FTIR, DSC, TGA, and SEM analysis were investigated. The parameters that affect the adsorption of serotonin on polymers such as temperature, pH and concentration were evaluated. The selectivity and reusability studies were also investigated.

acrylamide
methacrylic acid
methacrylamide
molecularly imprinted polymers
serotonin
  1. Yola M., Atar N.: Appl. Surf. Sci., 2018, 458, 648. https://doi.org/10.1016/j.apsusc.2018.07.142
  2. Mathews C., van Holde K.: Biochemistry: The Benjamin/Cummings Publ. Co., Redwood City, California 1990.
  3. Sengupta B., Chaudhuri S., Banerjee A., Sengupta P.: Chem. Biodivers., 2004, 1, 868. https://doi.org/10.1002/cbdv.200490069
  4. Suedee R., Seechammanturakit V., Suksuwan A., Canyuk B.: Int. J. Mol. Sci., 2008, 9, 2333. https://doi.org/10.3390/ijms9122333
  5. Patra S., Roy E., Madhuri R., Sharma P.: Anal. Chim. Acta, 2016, 918, 77. https://doi.org/10.1016/j.aca.2016.02.046
  6. Yan H., Row H.: Int. J. Mol. Sci., 2006, 7, 155. https://doi.org/10.3390/i7050155
  7. JeCho S., Noh H., Won M. et al.: Biosens. Bioelectron., 2018, 99, 471. https://doi.org/10.1016/j.bios.2017.08.022
  8. Hawkins D., Stevenson D., Reddy S.: Anal. Chim. Acta, 2005, 542, 61. https://doi.org/10.1016/j.aca.2005.01.052
  9. Ayankojo A., Reut J., Öpik A. et al.: Proceed. Estonian Acad. Sci., 2018, 67, 138. https://doi.org/10.3176/proc.2018.2.04
  10. Gálvez A., Mayorga-Matinez C., Parolo C. et al.: Electrochem. Commun., 2017, 82, 6. https://doi.org/10.1016/j.elecom.2017.07.007
  11. O’Mahony J., Molinelli A., Nolan K. et al.: Biosens. Bioelectron., 2005, 21, 1383. https://doi.org/10.1016/j.bios.2005.05.015
  12. Vazquez M., Spivak D.: J. Polym. Sci., 2004, 42, 3668. https://doi.org/10.1002/pola.20186
  13. Takeuchi T., Haginaka J.: J. Chromatogr. B, 1999, 728, 1. https://doi.org/10.1016/S0378-4347(99)00057-2
  14. Tooth B., Pap T., Horvath V., Horvai G.: Anal. Chim. Acta, 2007, 591, 17. https://doi.org/10.1016/j.aca.2007.01.016
  15. Peeters M., Troost F., Van Grinsven B., et al.: Sensor. Actuat. B-Chem., 2012, 172, 602. https://doi.org/10.1016/j.snb.2012.05.040
  16. Turiel E., Esteban A.: Anal. Chim. Acta, 2010, 668, 87. https://doi.org/10.1016/j.aca.2010.04.019
  17. Urban J., Jandera P., Schoenmakers P.: J. Chromatogr. A, 2007, 1150, 279. https://doi.org/10.1016/j.chroma.2006.09.065
  18. Wulff G., Poll H.: Macromol. Chem. Phys., 1997, 188, 741. https://doi.org/10.1002/macp.1987.021880408
  19. Okutucu B.,Telefoncu A.: Talanta, 2008, 76, 1153. https://doi.org/10.1016/j.talanta.2008.05.033
  20. Chattopathyay A., Rukmini R., Mukherjee S.: Biophys. J., 1996, 71, 1952. https://doi.org/10.1016/S0006-3495(96)79393-1
  21. Ewing G.: Instrumental Methods of Chemical Analysis, 4.edn. McGraw-Hill,Tokyo 1975.
  22. Bayari S., Ide S.: Spectrochim. Acta A, 2003, 59, 1255. https://doi.org/10.1016/S1386-1425(02)00308-6
  23. Lagutschenkov A., Langer J., Berden G. et al.: J. Phys. Chem. A, 2010, 114, 13268. https://doi.org/10.1021/jp109337a
  24. Peniche C., Argüelles-Monal W., Davidenko N. et al.: Biomater., 1999, 20, 1869. https://doi.org/10.1016/S0142-9612(99)00048-4
  25. Işikver Y., Saraydin D.: Polym. Eng. Sci., 2015, 55, 843. https://doi.org/10.1002/pen.23950
  26. Barati A., Kazemi E., Dadfarnia S., Shabani A.: JIEC, 2017, 46, 212.
  27. Okutucu B.,Önal S.: Talanta, 2011, 87, 74. https://doi.org/10.1016/j.talanta.2011.09.043
  28. Rudnick G., Kirk K., Fishkes H., Schuldiner S.: J. Biolog. Chem., 1989, 264, 14865.
  29. Giles C., Macewan T., Nakhwa S., Smith D.: Journal of Chemical Society, 1960, 3973. https://doi.org/10.1039/jr9600003973
  30. Işikver Y.: Fibers and Polymers, 2017, 18, 2070. https://doi.org/10.1007/s12221-017-7215-7
  31. Saraydin D., Karadağ E.: Tr. J. Chem., 1996, 20, 234.