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  3. Volume 17, Number 3, 2023
  4. Synthesis and Antimicrobial Activities of Salicylaldehyde Schiff Base-Cu(II) Complex and Its Catalytic Activity in N-Arylation Reactions

Synthesis and Antimicrobial Activities of Salicylaldehyde Schiff Base-Cu(II) Complex and Its Catalytic Activity in N-Arylation Reactions

JCCT.
2023;
Volume 17, Number 3
: pp. 557 - 566
https://doi.org/10.23939/chcht17.03.557
Authors:
  1. Afrooz Majdi-Nasab
  2. Fariba Heidarizadeh
  3. Hossein Motamedi
1
Shahid Chamran University of Ahvaz
2
Shahid Chamran University of Ahvaz
3
Shahid Chamran University of Ahvaz

Salicylaldehyde Schiff base-Cu complex (1:1 [M:L] chelate) was synthesized using salicylaldehyde, urea, and CuCl2. Its catalytic activity was then assessed in N-arylation of aromatic amines (1H-indole, 1H- pyrazole, 1H-imidazole, 1H-benzo[d][1,2,3]triazole, and aniline) with aryl halides. This reaction does not need aryl boronic acids as the active aryl source or palladium-based catalyst. Cu is cheaper than many other catalysts, and required ligands usually having quite simple structure and being inexpensive. On the other hand, with a proper ligand selection we can have a modified solubility, reactivity, and reaction efficiency. The structure and composition of this novel complex were approved by FT-IR, UV-Vis, atomic absorption spectroscopy, elemental analysis, and TGA/DTA. Investigating the antibacterial activity of the Cu complex suggests a significant antibacterial activity against standard species Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis.

salicylaldehyde Schiff base-Cu complex
antimicrobial study
catalytic activity
N-arylation
aryl halide
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