Methods for the synthesis of thiosulfoesters with a pyrimidine moiety were investigated by the interaction of sulfinic acids with 4,6-dimethylpyrimidine-2-yl sulfenamide. The interaction of 4,6-dimethylpyrimidin-2-yl esters of aromatic thiosulfoacids with amines (benzylamine, morpholine, ammonia) was investigated.
Derivatives of pyrimidine are the object of interest to researchers working in the field of medical chemistry. However, despite the rich history of searching for potential biologically active agents among substances containing this heterocyclic fragment, their potential is still unused. There are vitamins, vasodilators, antidiabetic, antibacterial, antimalarial substances among the derivatives of pyrimidine. A special group among the biologically active compounds is sulfurcontaining derivatives of pyrimidine (sulfides, salts of sulfonic acids, sulfonamides, sulfenamides, disulfides).
Cyanuric chloride is a valuable starting agent for the direct obtaining of highly structured molecules. The substitution of chlorine atoms in the molecule of cyanuric chloride by various pharmacophores’ fragments provides the obtaining a number of 1,3,5-triazine derivatives, among which the promising biologically active substances showing antimicrobial, anticancer, antimalarial and antiviral activity were detected.
A number of carboxyalkyl thiosulfosters were synthesized by the alkylation of sodium and potassium salts of aromatic thiosulfonic acid with cyclic esters of carboxylic acids and their drug-like parameters were calculated. Prediction of the biological activity of synthesized thiosulfoesters was realized by means of the PASS computer program. Синтезовано ряд карбоксиалкілових тіосульфоестерів алкілуванням натрієвих і калієвих солей ароматичних тіосульфокислот і визначено їх лікоподібні (“drug-like”) характеристики.