1. JCCT
  2. All Volumes and Issues
  3. Volume 15, Number 1, 2021
  4. The Development, Evaluation, and Antioxidant Activity Analysis of Chitosan Microcapsules Containing Red Ginger Oleoresin with Sodium Tripolyphosphate Prepared by Emulsion Cross-linking Technique

The Development, Evaluation, and Antioxidant Activity Analysis of Chitosan Microcapsules Containing Red Ginger Oleoresin with Sodium Tripolyphosphate Prepared by Emulsion Cross-linking Technique

JCCT.
2021;
Volume 15, Number 1
: pp. 40 - 46
https://doi.org/10.23939/chcht15.01.040
Authors:
  1. Jayanudin
  2. Mohammad Fahrurrozi
  3. Sang Kompiang Wirawan
  4. Rochmadi
1
Chemical Engineering Department, Faculty of Engineering, Universitas Gadjah Mada Jl. Grafika, Chemical Engineering Department, Faculty of Engineering, Universitas Sultan Ageng Tirtayasa Jl. Jenderal Sudirman
2
Chemical Engineering Department, Faculty of Engineering, Universitas Gadjah Mada Jl. Grafika
3
Chemical Engineering Department, Faculty of Engineering, Universitas Gadjah Mada Jl. Grafika
4
Chemical Engineering Department, Faculty of Engineering, Universitas Gadjah Mada Jl. Grafika

In this study, chitosan-based carrier of red ginger oleoresin was prepared using the emulsion cross-linking technique with sodium tripolyphosphate (TPP) as a cross-linking agent. The effect of chitosan and TPP concentration, as well as pH on the encapsulation efficiency, particle size and characterization of chitosan microcapsule was determined. The antioxidant activity of microcapsules was analyzed. Chitosan microcapsules containing red ginger oleoresin were produced although with non-smooth surfaces.

antioxidant activity
red ginger oleoresin
chitosan microcapsule
emulsion cross-linking
sodium tripolyphosphate
  1. Abu-Thabit N., Makhlouf A.: Historical Development of Drug Delivery Systems: From Conventional Macroscale to Controlled, Targeted, and Responsive Nanoscale Systems. [in:] Makhlouf A., Abu-Thabit N. (Eds.), Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Woodhead Publishing 2018, 1-41. https://doi.org/10.1016/B978-0-08-101997-9.00001-1
  2. Kotze A., Luessen H., Thanou M. et al.: Chitosan and Chitosan Derivatives as Absorption Enhancers for Peptide Drugs Across Mucosal Epithelia [in:] Mathiowitz E., Chickering III D., Lehr C. (Eds.), Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development. CRC Press 2019, 341-386.
  3. Jayanudin, Fahrurrozi M., Wirawan S., Rochmadi: J. Appl. Biomater. Funct. Mater., 2019, 17, 1. https://doi.org/10.1177/2280800018809917
  4. Jameela S., Jayakrishnan A.: Biomaterials, 1995, 16, 769. https://doi.org/10.1016/0142-9612(95)99639-4
  5. Ofokansi K., Kenechukwu F., Isah A., Okigbo E: Trop. J. Pharm. Res., 2013, 12, 19. https://doi.org/10.4314/tjpr.v12i1.4
  6. Campos E., Coimbra P., Gil M: Polym. Bull., 2013, 70, 549. https://doi.org/10.1007/s00289-012-0853-4
  7. Akolade J., Oloyede H., Salawu M et al.: J. Drug Deliv. Sci. Technol., 2018, 45, 11. https://doi.org/10.1016/j.jddst.2018.02.001
  8. Jarudilokkul S., Tongthammachat A., Boonamnuayvittaya V.: Korean J. Chem. Eng., 2011, 28, 1247. https://doi.org/10.1007/s11814-010-0485-z
  9. Alqahtani F., Aleanizy F., El Tahir E. et al.: Saudi Pharm. J., 2019, 27, 82. https://doi.org/10.1016/j.jsps.2018.08.001
  10. Csaba N., Köping-höggård M., Alonso M.: Int. J. Pharm., 2009, 382, 205. https://doi.org/10.1016/j.ijpharm.2009.07.028
  11. El-Ghorab A., Nauman M., Anjum F. et al.: J. Agric. Food Chem., 2010, 58, 8231. https://doi.org/10.1021/jf101202x
  12. Vaidya S., Bhosale R., Singhal R.: Dry. Technol., 2006, 24, 983. https://doi.org/10.1080/07373930600776159
  13. Jayanudin, Fahrurrozi M., Wirawan S., Rochmadi: Res. J. Pharm. Technol., 2018, 11, 3431. https://doi.org/10.5958/0974-360X.2018.00633.9
  14. Tan L., Chan L., Heng P.: J. Microencapsul., 2005, 22, 253. https://doi.org/10.1080/02652040500100329
  15. Jayanudin, Fahrurrozi M., Wirawan S., Rochmadi: Eng. Sci. Technol. Int. J., 2018, 22, 458. https://doi.org/10.1016/j.jestch.2018.11.008
  16. Jayanudin, Fahrurrozi M., Wirawan S., Rochmadi: Sustain. Chem. Pharm., 2019, 12, 100132. https://doi.org/10.1016/j.scp.2019.100132
  17. Gbadegesin M., Odunola O.: Br. J. Med. Med. Res., 2013, 3, 2141. https://doi.org/10.9734/BJMMR/2013/4356
  18. Liu H., Gao C.: Polym. Adv. Technol., 2009, 20, 613. https://doi.org/10.1002/pat.1306
  19. Esquivel R., Juárez J., Almada M. et al.: Int. J. Polym. Sci., 2015, 2015. https://doi.org/10.1155/2015/502058
  20. Patil S., Gupta V., Gupta K., Doddayya H.: J. Biomed. Pharm. Res., 2014, 3, 51.
  21. Hasheminejad N., Khodaiyan F., Safari M.: Food Chem., 2019, 275, 113. https://doi.org/10.1016/j.foodchem.2018.09.085
  22. Tripathy S., Das S., Prasad S. et al.: Int. J. Pharm., 2012, 434, 292. https://doi.org/10.1016/j.ijpharm.2012.05.064
  23. Omar Zaki S., Ibrahim M., Katas H.: J. Nanotechnol., 2015, 2015. https://doi.org/10.1155/2015/919658
  24. Ganesh S., Kumar D., Kumar B. et al.: Asian J. Pharm. Clin. Res., 2010, 3, 179.
  25. Hosseini S., Zandi M., Rezaei M., Farahmandghavi F.: Carbohydr. Polym., 2013, 95, 50. https://doi.org/10.1016/j.carbpol.2013.02.031
  26. Kedare S., Singh R.: J. Food Sci. Technol., 2011, 48, 412. https://doi.org/10.1007/s13197-011-0251-1
  27. Eleazu C., Amadi C., Iwo G. et al.: Clin. Toxicol., 2013, 3, 1.
  28. Murthy P., Gautam R., Pura Naik J.: J. Food Process. Preserv., 2015, 39, 1905. https://doi.org/10.1111/jfpp.12428
  29. Bellik Y.:Asian Pacific J. Trop. Dis., 2014, 4, 40. https://doi.org/10.1016/S2222-1808(14)60311-X