The quintessence of an information security (IS) of cyber-physical systems (CPS) was presented, which is deployed on the level of complex security system (CSS) creation paradigm and conception as well as the CSS universal platform in the field “threats – profiles – tools”; it is also implemented in the part of CSS integral model of cyber-physical system “iPhone – Wi-Fi, Bluetooth – sensors” and cryptographic protection of CPS wireless communication environment based on block data encryption of algorithm “Kalyna”. Use of such basic approach and three-level CPS will allow creating of high effective information security technologies of each CPS segments – cyberspace (CS), communication environment (CE), physical space (PS) as well as the whole three-level structure.
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