drug delivery systems

Developing Materials for Biodegradable Otolaryngological Stents

Materials for otolaryngological stents have to be characterized by good tensile strength, wear resistance, biocompatibility, and specific degradation time. This work aimed to synthesize polyurethanes based on various biodegradable polyol blends. Their biodegradability and mechanical properties were tested and compared to commercial BIOFLEX material.

Researches of Amphiphilic Properties of Copolyesters with Chromophore Groups

The distribution coefficients of macromolecules of aminofunctional copolyesters with chromophore groups in the n-octanol–water system, as well as experimental and calculated characteristics of their hydrophilic-lipophilic balance (HLB) have been determined. A multiple regression analysis has been carried out and interpolation equation of the lipophilicity coefficient has been derived depending on the parameters characterizing the qualitative and quantitative composition of the copolyester.

Structural and Colloidal-Chemical Characteristics of Nanosized Drug Delivery Systems Based on Pegylated Comb-Like Carriers

Novel comb-like polymeric and oligomeric drug carriers combining backbone – copolymers of 5-tert-butylperoxy-5-methyl-1-hexene-3-yne (VEP) and glycidyl methacrylate (GMA) – and side PEG chains of various lengths were synthesized. Nanosized delivery systems containing conjugates of water soluble anticancer drug Doxorubicin were developed. The structures of copolymers and their conjugates with drugs were confirmed by IR-spectroscopy.

Amphiphilic cholesterol containing polymers for drug delivery systems

The interaction of binary copolymers poly(maleic anhydride-co-poly(ethylene glycol) methyl ether methacrylate) with cholesterol results in formation of cholesterol containing polymers, which contain from 4.6 to 46.0 mol % monocholesteryl maleic links. Their structure was confirmed using functional analysis and IR spectroscopy. Acidic and anhydride links of these copolymers form polymeric salts if react with alkali. These salts are surfactants which in aqueous medium form a hierarchy micelles and micellar aggregates depending on the copolymer concentration.