Structural and Colloidal-Chemical Characteristics of Nanosized Drug Delivery Systems Based on Pegylated Comb-Like Carriers

Автори: 
Anna Riabtseva, Nataliya Mitina, Nataliya Boiko, Sergiy Garasevich, Igor Yanchuk, Rostyslav Stoika, Oleksandr Slobodyanyuk and Alexander Zaichenko

Novel comb-like polymeric and oligomeric drug carriers combining backbone – copolymers of 5-tert-butylperoxy-5-methyl-1-hexene-3-yne (VEP) and glycidyl methacrylate (GMA) – and side PEG chains of various lengths were synthesized. Nanosized delivery systems containing conjugates of water soluble anticancer drug Doxorubicin were developed. The structures of copolymers and their conjugates with drugs were confirmed by IR-spectroscopy. Structural and colloidal-chemical properties of water drug delivery systems were studied using photoluminescent (PL), UV-spectroscopy techniques, surface tension measurements and dynamic light scattering. The scheme of the immobilization of water soluble doxorubicin on developed PEGylated polymeric carriers was assumed.

[1] Dutta R.: Current Pharm. Design, 2007, 13, 761.
[2] Uchegbu I. and Schatzlein A.: Polymers in Drug Delivery, 2006, 243.
[3] Geng F., Shen Y., Peng B. et al.: Conf. Proc. IEEE Eng. Med. Biol. Soc., 2005, 1, 508.
[4] Manabe N., Hoshino A., Liang Y. et al.: IEEE Trans. Nanobioscience, 2006, 5, 263.
[5] Veronese F. and Pasut G.: Drug Discovery Today, 2005, 10, 1451.
[6] Rangel-Yagui C., Pessoa-Jr A. and Tavares L.: J. Pharm. Pharmaceut. Sci., 2005, 8, 147.
[7] Batrakova E., Bronich T., Vetro J. and Kabanov A.: [in:] Torchilin V. (Ed.), Nanoparticulates as Drug Carriers. Imperial College Press, London 2006.
[8] Duncan R.: Nature Rev. Cancer, 2006, 6, 688.
[9] Torchilin V.: J. Contr. Release, 2001, 73, 137.
[10] Jones M.-C. and Leroux J.-C.: Eur. J. Pharm. Biopharm., 1999, 48, 101.
[11] Kataokaa K., Harada A. and Nagasaki Y.: Adv. Drug Delivery Rev., 2001, 47, 113.
[12] Yurzhenko T. et al.: Uspekhi Khimii Organicheskikh Peroksidnykh Soedineniy i Autokislenie. Khimiya, Moskwa 1969.
[13] Fainermanand V. and Mille R.: [in:] Miller R. and Liggieri L. (Eds.), Bubble and Drop Interfaces in Progress in Colloid and Interface  Science, V.2. Brill, Leiden 2009.