Циклоконденсацією тетрагідропіримідин-2(1Н)-ону з 2-бромo-1-арилетанонами отримано низку 3-aрил-6,7-дигідрo-5H-[1,3]тіазоло[3,2-a]піримідинів. Встановлено, що природа замісника в ароматичному ядрі фенацилброміду суттєво позначається на перебігу такого типу реакції. Зокрема, у разі 2-бромo-1-(4-гідроксифеніл)етанону цільовий біциклічний продукт утворюється внаслідок 4 год кип'ятіння в етанолі, натомість для циклоконденсації тетрагідропіримідин-2(1Н)-тіону з іншими бромометиларилкетонами час реакції становив 10 год. Знайдено, що результатом взаємодії тетрагідропіримідин-2(1Н)-тіону та 2-бромo-1-(4-хлорофеніл)етанону впродовж 4 год є продукт S-алкілювання – 1-(4-хлорофеніл)-2-[(1,4,5,6-тетрагідропіримідин-2-іл)тіо]етанон, внутрішньомолекулярна циклізація якого під дією H3PO4 приводить до 3-(4-хлорофеніл)-6,7-дигідро-5H-[1,3]тіазоло[3,2-a]піримідину. Результати проведеного біоскринінгу синтезованих 3-aрил-6,7-дигідрo-5H-[1,3]тіазоло[3,2-a]піримідинів продемонстрували їхню помірну антимікробну активність і дали змогу виявити потенційний синтетичний антиоксидант – 3-(4-фторофеніл)-6,7-дигідрo-5H-[1,3]тіазоло[3,2-a]піримідин (І = 88.2%).
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