Synhtesis, Structure, Characteristics of Zn(II) and Cd(II) Coordination Compounds with 3-Methoxybenzene Acid Hybrazid and their Biological Activity

Ljudmila Roman and Stepan Chundak

Zinc(II) and cadmium(II) coordination compounds with 3-methoxybenzene acid hydrazide have been received from the hot ethanol or hydra-ethanol solutions in slightly acidic environment. Composition of the synthesized complexes is suggested on the basis of chemical analysis and the study of electrical conductivity of their solutions. The structure of the coordination compounds is established with the help of 1Н NMR and IR-spectroscopy and thermogravimetry as well as quantum-chemical calculations in the approximation of PM3. Two molecules of organic ligand in amidohydrazonic form take part in the building of strong Zn(II) and Cd(II) coordination compounds with 3-methoxybenzene acid hydrazide. In this process their coordination with the central metal ion proceeds chelate-bidentately with the formation of С=О→Ме and Ме←NH2 bonds. Octahedral surrounding of the central atom is added with anions of (NO3– or Cl–, respectively) acidic remains or with water molecule. The synthesized coordination compounds show antibacterial properties against microorganisms of the following strains: Acinetobacter baumanni, Sarcina flava, Pseudomonas aeruginosa, Streptococcus pneumoniae, and Bacillus subtilis as well as bacteriostatic properties against Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae, MRSA, Enterobacter cloaceae, and Klebsiella oxytoca.

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