Synhtesis, Structure, Characteristics of Zn(II) and Cd(II) Coordination Compounds with 3-Methoxybenzene Acid Hybrazid and their Biological Activity

Автори: 
Ljudmila Roman and Stepan Chundak

Zinc(II) and cadmium(II) coordination compounds with 3-methoxybenzene acid hydrazide have been received from the hot ethanol or hydra-ethanol solutions in slightly acidic environment. Composition of the synthesized complexes is suggested on the basis of chemical analysis and the study of electrical conductivity of their solutions. The structure of the coordination compounds is established with the help of 1Н NMR and IR-spectroscopy and thermogravimetry as well as quantum-chemical calculations in the approximation of PM3. Two molecules of organic ligand in amidohydrazonic form take part in the building of strong Zn(II) and Cd(II) coordination compounds with 3-methoxybenzene acid hydrazide. In this process their coordination with the central metal ion proceeds chelate-bidentately with the formation of С=О→Ме and Ме←NH2 bonds. Octahedral surrounding of the central atom is added with anions of (NO3– or Cl–, respectively) acidic remains or with water molecule. The synthesized coordination compounds show antibacterial properties against microorganisms of the following strains: Acinetobacter baumanni, Sarcina flava, Pseudomonas aeruginosa, Streptococcus pneumoniae, and Bacillus subtilis as well as bacteriostatic properties against Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae, MRSA, Enterobacter cloaceae, and Klebsiella oxytoca.

[1] Harikumaran N. and Thankamani D.: Koord. Khimiya, 2010, 36, 261.
[2] Gusev V., Radushev A., Slepukhin P. and Vnutskikh Zh.: Zh. Neorg. Khim., 2008, 53, 83. 
[3] Chundak S., Leovac V., Obadovic D. and Petrovic D.: Transition Met. Chem., 1986, 11, 308.
[4] Shulgin V., Kopnik O. and Seredyuk N.: Zh. Neorg. Khim., 1993, 38, 637.
[5] Shulgin V., Konnik O. and Chirva V.: Zh. Neorg. Khim., 1991, 26, 960.
[6] Kharitonov Yu. and Machkhoshvili R.: Zh. Neorg. Khim., 1972, 17, 3268.
[7] Yaul A., Dhande V., Bhadange S. and Aswar A.: Zh. Neorg. Khim., 2011, 56, 589.
[8] Gerbeleu N., Chundak S., Manole S. and Butsko S.: Zh. Neorg. Khim., 1975, 20, 1632.
[9] Sukharev S.: Doct. thesis, Physico-Khim. Inst., Odesa 2012.
[10] Delegan-Kokayko S.: PhD thesis, Uzhgorod Nats. Univ., Uzhgorod 2013.
[11] Dzharadat N.: PhD thesis, Nats. Pharmavc. Avad., Kharkіv 2000.
[12] Xue L., Zhao G., Han Y. and Feng Y.: Coordin. Khim., 2011, 37, 261.
[13] Veygand-Khilgetag N.: Metody Eksperimenta v Organicheskoi Khimii. Khimiya, Moskwa 1969. 
[14] Shvartsenbakh G. and Flashka G.: Kompleksonometricheskoe Titrovanie. Khimiya, Moskwa 1970.
[15] Klimova V.: Osnovnye Micrometody Analiza Organicheskikh Soedineniy. Khimiya, Moskwa 1975.
[16] Uendland U.: Termicheskie Metody Analiza. Mir, Moskwa 1978.
[17] Orozco M., Bachs M. and Luque F.: J. Comp. Chem., 1995, 16, 563.
[18] Zagradnik R. and Polak R.: Osnovy Kvantovoi Khimii. Mir, Moskwa 1979.
[19] Glikina F. and Klyuchnikov N.: Khimiya Kompleksnykh Soedineniy. Prosveshchenie, Moskwa 1972. 
[20] Nakamoto K.: IK-spectry i Spectry KR Neorganicheskikh i Koordinatsyonnykh Soedineniy. Mir, Moskwa 1991.
[21] Prech E., Byulmann F. and Affolter K.: Opredelenie Stroeniya Organicheskikh Soedineniy. Mir, Moskwa 2006.
[22] Kostrzhitskiy A.: Fіzichna ta Koloidna Khіmіya. Centre uchb. lіter., Kyiv 2007.
[23] Roman L., Chundak S., Dashkevich M. and Marіychuk R.: Nauk. Vіsnik Uzhg. Nats. Univ., 2011, 26, 60.
[24] Bulatov M. and Kalinkin I.: Prakticheskoe Rukovodstvo po Fotometricheskim Metodam Analiza. Khimiya, Leningrad 1986.
[25] Bean D., Krahe D. and Wareham D.: Ann. Clin. Microbiol. Antimicrob., 2008, 7, 13.