In the paper on the base of analyzing of Neogene sediments` structure of Transcarpathian depression the Neogene geodynamics of the region is traced. Based on comparisons with modern data it is concluded that modern geodynamic regime of depressions` lithosphere is some continuing of transformation of Neogene geodynamic process from subcarpathian to the zonal ones with the growing of display of processes with transversal pattern and with their spatial migration (in general – from the southeast to the northwest). It is shown that the middle subcarpathian belt of heightened seismic activity in depressions is closely related to disjunctive dislocations of Neogene initiation of its axial zone.