The article analyzes and summarizes the latest achievements in the field of polymer systems for controlled release devices based on hydrogel materials. Possible directions of drug delivery are presented, including the use of granular hydrogels, which work on the principle of drug sorption − release in the body.
The effect of the presence of finely dispersed metal fillers of various natures (Zn, Co, Ni) on the thermophysical characteristics (Vick heat resistance, glass transition temperature) of polyvinylpyrrolidone block copolymers with 2-hydroxyethylmethacrylate was studied. It was found that the heat resistance of the obtained composites significantly exceeds the heat resistance of unfilled copolymers and is in the range of 360-395K, depending on the nature and content of the metal filler.
The possibility of using hydrogels based on copolymers of polyvinylpyrrolidone with 2 hydroxyethylmethacrylate to saturate them with plant extracts was established. Hydrogel materials were obtained with extracts of Calendula officinalis and Arnica montana. The sorption capacity of the hydrogels regarding the extract data was determined.
The paper presents the results of the study of copolymerization of 2-hydroxyethylmethacrylate (HEMA) with polyvinylpyrrolidone (PVP) under the action of two-component initiation systems of iron (II) sulfate/radical type initiator. The influence of the nature of the radical initiator (In) in the FeSO4/In system on the behavior of the polymerization of HEMA/PVP compositions, structural parameters of the polymer matrix network and properties of hydrogels based on pHEMA-gr-PVP copolymers were established.
The research results of surface adsorption magnitude and tensile strength of combined polyamide-hydrogel membranes, depending on the content of the hydrogel lining membrane are presented in the article. It was found that the molecular weight variation of PVP, both in the structure of copolymer and in modifying blend, as well as the time of staying hydrogel film in the modifying solution allow to regulate the properties of combined membranes directly, in particular, its strength and permeability.
The course of the grafted polymerization of 2-hydroxyethylmethacrylate on polyvinylpyrrolidone with the formation of a reticulated copolymer with simultaneously chemical reduction of nickel ions is confirmed. The influence of the reduction process on the structural parameters of the polymeric matrix – the grafting efficiency and the content of polyvinylpyrrolidone in the copolymer, the molecular weight between crosslinks is established. The influence of the presence of polymer-monomer composition components on the particles formation of nickel filler is investigated.
The kinetics of polymerization of 2-hydroxyethyl methacrylate with polyvinylpyrrolidone in a thin layer were studied. The dependences of the conversion for polymerization HEMA with PVP in mass and in solvent were determined. (Co)polymerization exotherms for the reaction in mass were calculated. The reaction order by initiator, monomer and polymer was determined and the mathematical dependence of the total rate of grafted copolymerization of HEMA to PVP was calculated.
Composite hydrogel metal-filled materials in many cases during the operation are used in the form of films, in medicine these are membrane different kind, of transdermal drugs, implants, elements of medical equipment intended for installation of a reliable contact with the human body, the instrument making-elements of different sensors (humidity, temperature, pressure, concentration of gaseous and liquid products), etc.
Polymer hydrogels, which are close to biological cells in their physical state, have proven to be effective in medicine and pharmacy. However, in practice the wide usage of hydrogel products is limited by their low mechanical strength, even though generally the application of hydrogels has a great potential . Recently, the interest to the polymer hydrogel materials, that have high mechanical strength in a hydrated state along with the hydrophilic and diffusion-transport properties, has increased.
Розроблено методику одержання композиційних полімерних мембран модифікуванням поверхні гідрогелів тонким шаром полімеру. Підібрані склади і синтезовані ультратонкі плівкові мембрани з сумішей ПА-6/ПВП методом “сухого формування” з розчину. Одержано композиційні полімерні мембрани на основі рідкостуктурованих кополімерів ГЕМА/ПВП, які зміцнені наношаром ПА-6/ПВП і досліджені їх експлуатаційні характеристики. Встановлено, що варіювання складами гідрогелевого і модифікувального шарів і режимами формування композиційних мембран можна направлено регулювати їхню міцність і проникність.