Hydrogels are one of the perspective classes of polymer systems that embrace numerous biomedical and pharmaceutical applications. Hydrogels have become very popular due to its unique properties such as high water content, softness, elasticity and biocompatibility. Natural and synthetic hydrophilic polymers can be physically or chemically crosslinked to obtain hydrogels. Their resemblance to living tissue opens up many possibilities for applications in biomedical fields. Hydrogels are widely used for various biomedical applications − tissue engineering, molecular imprinting, monopoles as dressings, drug delivery and other.
The aim of the present research is obtaining hydrogel composites filled with gelatin for cosmetic application.
By graft-polymerization of hydrophilic functional monomers in an aqueous medium obtained spatially crosslinked polymer hydrogels filled with gelatin. For this purpose, a process conducted in water solution at different ratio of monomers (acrylamide (АкАм), acrylic acid (AcA)) in presence gelatin (the initiator K2S2O8, temperature 60 °C during 2 hours) and modified gelatin by peroxide oligomer VEP-MA (2% by mass, temperature 60 °C during 5 hours). In the case of using the modified gelatin of the initiation of polymerization occurred due to the decomposition of peroxide groups immobilized to the surface of the gelatin molecules. The study of the kinetics of swelling by gravimetric method, determined the rate constants of swelling and change of the sizes of the samples obtained in the swelling process of the hydrogel composites. Taking into account, the presented results are noticeable sharp increase in the maximum values of swelling samples graft-copolymers АкАм and AcA in comparison with the samples of grafted polyacrylamide. This is probably due to the formation of an additional stitched mesh between grafted copolymere through centers of interaction between functional groups of macromolecules –NH2 and –COOH. Composites filled with modified gelatin show mass storage, and therefore shape, with long periods in a water environment. This suggests that the modified gelatin has the satisfactory properties of the crosslinked agent and optimal content in hydrogel composites must present 5% by mass.
1. Daniele M. A., Adams A. A., Naciri J., North S. H. & Ligler F. S. 35(2014) Interpenetrating networks based on gelatin methacrylamide and PEG formed using concurrent thiol click chemistries for
https://doi.org/10.1016/j.biomaterials.2013.11.009
hydrogel tissue engineering scaffolds, Biomaterials, 1845-1856.
2. Azami M., Moosavifar M. J., Baheiraei N., Moztarzadeh F. & Ai J. 100 (2012) Preparation of a biomimetic nanocomposite scaffold for bone tissue engineering via mineralization of gelatin hydrogel and study of mineral transformation in simulated body fluid, J. Biomed. Mater. Res. A., 1347-1355.
https://doi.org/10.1002/jbm.a.34074
3. Emami, Z., Ehsani, M., Zandi, M., Foudazi, R. 198 (OCT 15 2018) Controlling alginate oxidation conditions for making alginate-gelatin hydrogels, Carbohydrate Polymers, 509-517.
https://doi.org/10.1016/j.carbpol.2018.06.080
4. Lowman, A. M. & Peppas N. A. 1 (1999). Hydrogels. Encyclopedia Controlled Release., 397-418.
5. Peppas N. A., Bures P., Leobandung W. & Ichikawa H. 50(1) (2000, July). Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm, 27-46.
https://doi.org/10.1016/S0939-6411(00)00090-4
6. Suvarna Kurhade, Munira Momin, Pallavi Khanekar & Supriya Mhatre. 5 (2013) Novel Biocompatible Honey Hydrogel Wound Healing Sponge for Chronic Ulcers, International Journal of
Drug Delivery, 353-361.
7. Habiboallah G., Nasroallah S. & Mahdi Z. 2008; 120. Histological evaluation of Curcuma longaghee formulation and hyaluronic acid on gingival
https://doi.org/10.1016/j.jep.2008.09.011
healing in dog // Journal of Ethnopharmacology, 335- 341.
8. Kim GH, Kang YM & Kang KN. 8(1). 2011 Wound. Dressings for Wound Healing and Drug, Delivery, Tissue Engineering and Regenerative Medicine. 1-7.
9. Chobit M. R., Tokariev V. S. & Voronov S. A. № 3. (2003) Modyfikatsiia tseliulozy funktsional- nymy olihoperoksydamy dlia oderzhannia bahatokomponentnykh polimernykh system, Dopovidi
Natsionalnoi akademii nauk Ukrainy, 156-161.
10. Chobit M. R., Bilozir R. M., Tokarev V. S.№868 (2017). Oderzhannia kompleksnykh hidroheliv poliakrylamidu, yak osnovy kosmetychnykh zasobiv. Visnyk Nats. un-tu "Lvivska politekhnika",
310-318.
11. Issa Katime & Eduardo Mendizábal. 1, 2010. Swelling Properties of New Hydrogels Based on the Dimethyl Amino Ethyl Acrylate Methyl Chloride Quaternary Salt with Acrylic Acid and 2-Methylene
https://doi.org/10.4236/msa.2010.13026
Butane-1,4-Dioic Acid Monomers in Aqueous Solutions, Materials Sciences and Applications, 162-167.
12. Chang-ShengWang, Nick Virgilio, Paula M. Wood-Adams & Marie-Claude Heuzey. 79 (2018) A gelation mechanism for gelatin/polysaccharide aqueous mixtures. Food Hydrocolloids. 462-472.
https://doi.org/10.1016/j.foodhyd.2018.01.016
13. B. Duan, L. A. Hockaday, K. H. Kang, J. T. Butcher. 101(2013). 3D bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels, J. Biomed. Mater. Res. A. 1255-1264.
https://doi.org/10.1002/jbm.a.34420