hydrogel

The various samples of pectins with degrees of esterification of 40-70% in the work were obtained using pectin with degree of esterification of 81.5%. It was shown that the determining factor for successful formation of hydrogel plates is the degree of esterification of polysaccharide. It was established that hydrogel plates obtained by the method of structuring of calcium salts are formed only on the basis of pectin with the degree of esterification less than 70%.

The possibility of using hydrogels,that are based on copolymers of polyvinylpyrrolidone with 2-hydroxyethylmethacrylate for saturation them with extracts of plants,was researched. Hydrogel materials with extracts of Calendula officinal is and Arnica montana were obtained. The sorption capacity of the hydrogels in relation to these extracts and the content of flavonoids in the extracts were determined  by using Ulab108UV.

Modern hydrogel healing therapies for damaged human skin, must perform a number of functions which are inherent for the skin: 1) preservation of thermal and water balance; 2) ensuring of oxygen penetration; 3) providing transportation of substances necessary for the functioning of the organism; 4) protection from mechanical damage. When using hydrogel coatings on damaged areas of the skin, they must perform, an additional function - prolonged delivery to the wound of therapeutic agents of various nature.

Polymer hydrogels, which are close to biological cells in their physical state, have proven to be effective in medicine and pharmacy. However, in practice the wide usage of hydrogel products is limited by their low mechanical strength, even though generally the application of hydrogels has a great potential . Recently, the interest to the polymer hydrogel materials, that have high mechanical strength in a hydrated state along with the hydrophilic and diffusion-transport properties, has increased.

Today in the world deepened researches on the synthesis and study of theproperties of hydrogel materials are held due to their promising use in many fields,in particular in pharmaceutics, electronic devices and engineering, biomedicine,bioengineering. Physico-chemical properties of hydrogels, so the spheres of theirpossible use are determined by the nature of the polymer, the degree of structuring,the ratio of components of the polymer: water.

This paper reports on a study of novel heterohydrogel materials with regular inclusions of the dispersed phase such as polystyrene latex nanoparticles. Synthesized 3D hydrogel matrices contain a balanced number of cross-links and a defined amount of polystyrene nanoparticles with 50 or 85 nm in radius. This study has shown that the obtained hydrogel matrices are capable of changing the swelling degree and their optical properties depending on the size and concentration of the dispersed nanoparticles.

The effect of the solubility parameter on the regularities of the hydrogel suspension obtaining based on the copolymers of 2-hydroxyethyl methacrylate and glіcidil metakrilat with polyvinylpirrolydone is investigated. The influence of the solvent nature on the diffusion processes in the suspension polymerization, the dispersion characteristics of hydrogel particles and kinetics of polymerization is determined.

The synthesis of polymers based on the 3-aminobenzenboroniс acid and reactionary poly (N-hydroxymethylacrylamide) via polymer-analogous transformations were researched. The polymer structure was confirmed and the optimal synthesis conditions were determined. Досліджено синтез полімерів на основі 3-амінобензенборонової кислоти та реакційноздатного полі(N-гідроксиметилакриламіду) через полімераналогічні перетворення. Підтверджено їх структуру та встановлені оптимальні умови синтезу. 

Розглянуто проблему введення ліпофільних лікарських препаратів в трансдер-
мальні системи доставки ліків, що створені на основі поліакриламідних гідрогелів. На
стадії структурування поліакриламіду та полі-N-(гідроксиметил)акриламіду як агент
міжфазного перенесення та ефективний солюбілізатор лікарських препаратів
використовували псевдополіамінокислоти. Показано, що при введенні дисперсії
псевдополіамінокислоти з солюбілізованим барвником Суданом ІІІ (Судан є аналогом
малорозчинних лікарських препаратів) солюбілізований гідрофобний Судан може бути

Методом полімераналогічних перетворень при взаємодії частини реакційноздат-
них метилольних груп полі(N-гідроксиметил) акриламіду та аміногрупи глутамінової
кислоти створено структуруючий агент з вільними карбоксильними групами в бокових
ланках. Створено нові гідрогелеві матриці з використанням як структуруючого агента
полі-N-(гідроксиметил)акриламіду, модифікованого глутаміновою кислотою. Ці
гідрогелі набувають ознак рН-чутливості, реагують на зміну природи середовища та