1. JCCT
  2. Всі випуски
  3. Випуск 17, Номер 3, 2023
  4. Вплив Твін 80 на стабільність і конформацію теломерної g-квадруплексної ДНК

Вплив Твін 80 на стабільність і конформацію теломерної g-квадруплексної ДНК

JCCT.
2023;
Випуск 17, Номер 3
: cc. 567 - 573
https://doi.org/10.23939/chcht17.03.567
Автори:
  1. Ismail A. Elhaty
1
Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Gelisim University

G-квадруплексна ДНК утворюється в теломері. Вона пригнічує фермент теломеразу, активний у більш ніж 85 % ракових клітин. У цій роботі було вивчено вплив Твін 80 на теломерну G-квадруплексну ДНК AGGG(TTAGGG)3 за допомогою спектроскопічної методики циркулярного дихроїзму. Отримані результати показали, що використання Твін 80 з теломерним квадруплексом є безпечним за концентрації до 1,0 %.

теломер
квадруплекс
Твін-80
циркулярний дихроїзм
конформація.
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