The paper presents the results of the study of copolymerization of 2-hydroxyethylmethacrylate (HEMA) with polyvinylpyrrolidone (PVP) under the action of two-component initiation systems of iron (II) sulfate/radical type initiator. The influence of the nature of the radical initiator (In) in the FeSO4/In system on the behavior of the polymerization of HEMA/PVP compositions, structural parameters of the polymer matrix network and properties of hydrogels based on pHEMA-gr-PVP copolymers were established.
The properties of nickel-filled copolymers of polyvinylpyrrolidone with 2-hydroxyethylmethacrylate and hydrogel materials based on them, obtained by the method of polymerization with simultaneous reduction of metal ions have been investigated. The influence of polymer-monomer composition formulation, content of metal-filler and conditions of Ni2+ reduction reaction on physico-mechanical, sorption, electrical and magnetic characteristics of obtained materials has been established.
The course of the grafted polymerization of 2-hydroxyethylmethacrylate on polyvinylpyrrolidone with the formation of a reticulated copolymer with simultaneously chemical reduction of nickel ions is confirmed. The influence of the reduction process on the structural parameters of the polymeric matrix – the grafting efficiency and the content of polyvinylpyrrolidone in the copolymer, the molecular weight between crosslinks is established. The influence of the presence of polymer-monomer composition components on the particles formation of nickel filler is investigated.
Composite hydrogel metal-filled materials in many cases during the operation are used in the form of films, in medicine these are membrane different kind, of transdermal drugs, implants, elements of medical equipment intended for installation of a reliable contact with the human body, the instrument making-elements of different sensors (humidity, temperature, pressure, concentration of gaseous and liquid products), etc.
The hydrogel film composites of biomedical purpose based on copolymers of polyvinylpyrrolidone with 2-hydroxyethylmethacrylate have been synthesized. The influence of filler nature, quantity and composition on the regularities of obtaining, structure and properties of hydrogels have been determined. Synthesized hydrogel composites are recommended to be used for the controlled drug release systems.
The research results of the hydrogels synthesis rules on the basis of 2-hydroxyethylmethacrylate-polyvinylpyrrolidone copolymers and effective ways of adjusting of their proper¬ties are given. Synthesized copolymers appeared to be effective materials for production of hydrophilic contact lenses.
The crosslinked copolymers of 2-hydroxyethylmethacrylate with polyvinylpyrrolidone as granules and membranes have been synthesized and their penetration and sorption-desorption properties have been investigated. The model of mass-transfer from the solid soluble surface through the hydrogel shell has been suggested. The developed materials are able to create encapsulated and granular polymer forms of drugs prolonged release.
The influence of a constant magnetic field on the polymerization kinetics and structural parameters of a hydrogel network on the basis of 2-hydroxyethylmethacrylate and polyvinylpyrrolidone compositions has been investigated. It has been shown that the magnetic field activates matrix polymerization of such compositions and assists in structure formation of copolymers with minor cross-link density. The efficiency of the developed polymeric materials used for production of ultrathin contact lenses has been confirmed.
Based on the experimental studies and mathematical modeling method, we have chosen the optimal conditions of the 2,3-dimetylbuta-1,3-diene and 2-hydroxyethylmethacrylate cyclization reaction with obtaining of 2-hydroxyethyl 1,3,4-trimethylcyclohex-3-encarboxylate.
Polymerization of hydroxyalkyl(meth)acrylates with polyvinylpyrrolidone has been investigated. Thus highly hydrophilic membranes have been obtained and several properties have been investigated including polymerization rate, viscosity, extinction, water permeability of the membranes, their tensile strength and tensile elongation at break. Parameters characterizing complex formation between monomer and polyvinylpyrrolidone are related to structural parameters of resulting copolymer networks.