Синтез та властивості фосфоровмісних псевдополіамінокислот поліестерного типу на основі n-похідних глутамінової кислоти

2022;
: cc. 51–58
1
Національний університет “Львівська політехніка”
2
Упсальський університет, відділ нанотехнологій і функціональних матеріалів
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Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies
4
Національний університет “Львівська політехніка”
5
Інститут біології тварин НААН
6
Lviv Polytechnic National University
7
Національний університет “Львівська політехніка”

Поліфосфоестери (ПФЕ) – це клас полімерів, що володіють високою хімічною функціональністю та здатністю до біологічного розкладання. Синтезовані нові поліфосфоестери на основі глутамінової кислоти за реакцією Стегліха. Розробленийсинтетичнийпідхіддозволяєконтролювати склад і структуру ПФЕ, а отже, їхфізичні та колоїдні властивості. Дослідження солюбілізації та цитотоксичностіinvitro довели потенціал застосування ПФЕ для доставки лікарських препаратів.

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